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NN9924

Phase 1

Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jan 3, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment155

FDA Designations

No designations recorded

Clinical trial landscape

NN9924 · 1 trial · 3 indications

Phase 1 1
NCT01037582A Two Part Trial Investigating the Safety of NN9924 in Healthy Male SubjectsDiabetes
COMPLETED155 Analytics
PHASE1COMPLETED
A Two Part Trial Investigating the Safety of NN9924 in Healthy Male Subjects
DiabetesUnlock trial analytics

Study Endpoints

Primary Endpoints

Number and severity of adverse events (AEs) recorded
from dosing to Day 22

Secondary Endpoints

The uptake in blood of oral NN9924 compared to i.v. and s.c. administration of the same compound
from 0 to 504 hours
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Trial part 1EXPERIMENTAL -
Trial part 2EXPERIMENTAL -

Interventions

NameTypeDescription
NN9924 (oral)DRUGSubjects will be randomized to receive a single dose of NN9924, at escalating dose levels. Progression to next dose will be based on safety evaluation.
placeboDRUGSubjects will receive a single dose of placebo as a comparator to NN9924, at all dose levels.
NN9924 (s.c.)DRUGAs an active comparator, one standard dose will be given s.c. (under the skin) at one study visit
NN9924 (i.v.)DRUGAs an active comparator, one standard dose will be given i.v. (into the vein) at one study visit.
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Eligibility Criteria

Age Range18 Years to 50 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male subjects with good general health as judged by the Investigator * Body weight of 65.0-95.0 kg (both inclusive) * Body Mass Index (BMI) of 18.5-27.5 kg/m\^2 (both inclusive) Exclusion Criteria: * Known or suspected allergy to trial product or related products * Acute inf...

Countries:United Kingdom
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Competitive Landscape -Diabetes Complications 6 trials (matched to "Diabetes")

Frequently asked questions about NN9924

What is NN9924 used for?

NN9924 is an investigational small molecule being developed for diabetes, including type 2 diabetes. It is in Phase 1 clinical development and has not been approved by regulatory authorities.

Who is developing NN9924?

NN9924 is being developed by Novo Nordisk A/S, a biopharmaceutical company traded on the New York Stock Exchange under the ticker NVO.

What phase is NN9924 in?

NN9924 is in Phase 1 clinical development. One Phase 1 trial has been completed, and the drug remains investigational.

What clinical trials is NN9924 in?

NN9924 has one completed Phase 1 trial, NCT01037582, which investigated the safety of NN9924 in healthy male subjects. The trial enrolled 155 participants and was conducted in the United Kingdom.

Is NN9924 being studied in healthy volunteers?

Yes, NN9924 has been studied in healthy volunteers. The completed Phase 1 trial, NCT01037582, enrolled healthy male subjects aged 18 years and older.