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NN1952

Phase 1

Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jul 25, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment84

FDA Designations

No designations recorded

Clinical trial landscape

NN1952 · 1 trial · 4 indications

Phase 1 1
NCT01028404A Two Part Trial Investigating NN1952 in Healthy Subjects and Subjects With Type 1 and Type 2 DiabetesDiabetes
COMPLETED84 Analytics
PHASE1COMPLETED
A Two Part Trial Investigating NN1952 in Healthy Subjects and Subjects With Type 1 and Type 2 Diabetes
DiabetesUnlock trial analytics

Study Endpoints

Primary Endpoints

Number and severity of adverse events for trial part 1
from visit 1 to visit 3
Number and severity of adverse events for trial part 2
from visit 1 to visit 6

Secondary Endpoints

Area under the serum insulin concentration-time curve after a single dose
after 12 hours
Area under the glucose infusion rate-time curve after a single dose
after 12 hours
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Trial part 1EXPERIMENTAL -
Trial part 2EXPERIMENTAL -

Interventions

NameTypeDescription
NN1952DRUGSubjects will be randomised to receive a single dose of NN1952, at escalating dose levels. Progression to next dose will be based on safety evaluation.
insulin aspartDRUGAs an active comparator, one standard dose will be given s.c. (under the skin) at all dose levels.
placeboDRUGSubjects will receive a single dose of placebo as a comparator to NN1952, at all dose levels.
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * FOR TRIAL PART 1, THE FOLLOWING APPLIES: * Gender: male * Age: 18-55 years * BMI (body mass index): 18-28 kg/m2 * Study participants considered to be healthy * FOR TRIAL PART 2, THE FOLLOWING APPLIES: * Gender: male or female of no childbearing potential * Age: 18-65 years * T...

Countries:Germany
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Competitive Landscape -Diabetes Complications 6 trials (matched to "Diabetes")

Frequently asked questions about NN1952

What is NN1952 used for?

NN1952 is an investigational small molecule being developed by Novo Nordisk for the treatment of diabetes, including type 1 and type 2 diabetes. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who is developing NN1952?

NN1952 is being developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker NVO. The drug is in Phase 1 clinical development for the treatment of diabetes.

What phase is NN1952 in?

NN1952 is in Phase 1 clinical development. It has completed one Phase 1 trial, and the drug remains investigational, meaning it has not been approved for commercial use.

What clinical trials is NN1952 in?

NN1952 has been studied in a completed Phase 1 trial with the identifier NCT01028404. This trial investigated the drug in healthy subjects and in subjects with type 1 and type 2 diabetes, enrolling 84 participants in Germany.

Is NN1952 the same as other diabetes drugs?

NN1952 is a distinct investigational small molecule developed by Novo Nordisk. It is being studied specifically for diabetes, but it is not the same as other marketed diabetes medications, as it is still in early clinical development.