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NN1218

Phase 1

Diabetes | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Dec 10, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment26
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01121289A Trial Investigating NN1218 in Subjects With Type 1 DiabetesPHASE1 COMPLETED 26Apr 1, 2010Jul 1, 2010Dec 10, 20131 Germany
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Study Endpoints
Primary Endpoints
Area under the serum NN1218 concentration-time curve
From 0-1 hours
Secondary Endpoints
Area under the serum NN1218 concentration-time curve
From 0-10 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
NN1218, formulation AEXPERIMENTAL -
NN1218, formulation BEXPERIMENTAL -
NN1218, formulation B (high)EXPERIMENTAL -
NN1218, formulation CEXPERIMENTAL -
NN1218, formulation DEXPERIMENTAL -
insulin aspartACTIVE_COMPARATOR -
Interventions
NameTypeDescription
NN1218DRUG0.2 U/kg body weight injected subcutaneously (under the skin)
insulin aspartDRUG0.2 U/kg body weight injected subcutaneously (under the skin)
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Type 1 diabetes mellitus for more than 12 months * Treated with multiple daily insulin injections or continuous subcutaneous insulin infusion (CSII) for more than 12 months * Body mass index (BMI) between 18.0-28.0 kg/m2 (both inclusive) Exclusion Criteria: * Subject who has...

Countries:Germany
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