Recent Updates
Recently added Catalysts

INV-202

Phase 2

Diabetic Kidney Disease | Small molecule | Nephrology |Novo Nordisk A/S|Last Updated: Aug 11, 2025

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment265

FDA Designations

No designations recorded

Clinical trial landscape

INV-202 · 3 trials · 3 indications

Phase 2 2Phase 1 1
NCT05891834Study of INV-202 in Patients With Obesity and Metabolic SyndromeObesity
COMPLETED243 Analytics
NCT05514548Phase 2 Study of INV-202 in Patients With Diabetic Kidney DiseaseDiabetic Kidney Disease
COMPLETED265 Analytics
PHASE2COMPLETED
Study of INV-202 in Patients With Obesity and Metabolic Syndrome
ObesityUnlock trial analytics
PHASE2COMPLETED
Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease
Diabetic Kidney DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

To evaluate the effect of INV-202 on body weight loss in participants with obesity and metabolic syndrome
Week 16

Mean change from baseline in body weight at Week 16 for INV-202 versus placebo

Change in UACR from baseline to W16
16 weeks

Measure of UACR at W16 in comparison to baseline to evaluate the effect of INV-202 in participants with diabetic kidney disease (DKD)

Number and Frequency of Adverse Events
28 Days

Safety and Tolerability as assessed by Adverse Events

Secondary Endpoints

To evaluate the effect of INV-202 on weight (marker of metabolic syndrome)
Week 16
To evaluate the effect of INV-202 on waist circumference (marker of metabolic syndrome)
Week 16
To evaluate the effect of INV-202 on lipids (marker of metabolic syndrome)
Week 16
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Low doseEXPERIMENTALINV-202, 10 mg
High doseEXPERIMENTALINV-202, 50 mg
PlaceboPLACEBO_COMPARATORPlacebo Matching size and number of tablets
Middle DoseEXPERIMENTALINV-202, 20 mg
INV 202 10 mgEXPERIMENTALINV-202 10 mg Arm
INV-202 25 mgEXPERIMENTALINV-202 25 mg Arm
INV-202EXPERIMENTALINV-202 25mg by mouth once daily

Interventions

NameTypeDescription
INV-202DRUGtablet, once daily, oral
PlaceboDRUGtablet, once daily, oral
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites24

Inclusion Criteria: 1\. Male and female participants from 18 to 75 years of age 2. Able and willing to provide informed consent and to comply with scheduled visits and study procedures 3. BMI ≥ 30 kg/m2 4. Presence of at least 3 of the 5 following criteria at screening: i. Increased waist circumfer...

Countries:CanadaUnited StatesGeorgiaHungaryIsraelMexicoSerbia
Unlock Eligibility Criteria

Frequently asked questions about INV-202

What is INV-202 used for?

INV-202 is an investigational small molecule being studied for diabetic kidney disease, obesity, and metabolic syndrome. It is developed by Novo Nordisk A/S (NVO). The drug is in Phase 2 clinical development, with completed trials in these indications.

Who makes INV-202?

INV-202 is developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker NVO. The drug is an investigational small molecule in Phase 2 clinical development for diabetic kidney disease, obesity, and metabolic syndrome.

What phase is INV-202 in?

INV-202 is in Phase 2 clinical development. It has completed Phase 2 trials in diabetic kidney disease and in obesity with metabolic syndrome. The drug is investigational and not yet approved by regulatory authorities.

What clinical trials is INV-202 in?

INV-202 has completed three clinical trials. NCT05282446 was a Phase 1 study in metabolic syndrome with 37 participants. NCT05514548 was a Phase 2 study in diabetic kidney disease with 265 participants. NCT05891834 was a Phase 2 study in obesity and metabolic syndrome with 243 participants.

Is INV-202 the same as other drugs?

INV-202 is a distinct investigational small molecule developed by Novo Nordisk A/S. It is being studied for diabetic kidney disease, obesity, and metabolic syndrome. No alternative names for INV-202 have been reported in clinical trial registries.