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Cagrilintide B

Phase 1

Overweight | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Sep 4, 2026

Target and mechanism

Target class-Tide (Peptide)
ModalitySmall molecule

Also known as Cagrilintide B and placebo semaglutide I

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment50

FDA Designations

No designations recorded

Clinical trial landscape

Cagrilintide B · 1 trial · 2 indications

Phase 1 1
NCT07605052A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body WeightOverweight
COMPLETED50 Analytics
PHASE1COMPLETED
A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body Weight
OverweightUnlock trial analytics

Study Endpoints

Primary Endpoints

AUCss: area under the total cagrilintide concentration-time curve at steady state after 5th dosing of cagrilintide
From Pre-dose at Day 29 to Day 36

Measured as hour\*nanomole per liter (h\*nmol/L).

Cmax,ss: maximum observed concentration of total cagrilintide at steady state after 5th dosing of cagrilintide
From Pre-dose at Day 29 to Day 36

Measured as nanomole per liter (nmol/L).

Secondary Endpoints

AUCss: area under the total cagrilintide concentration-time curve at steady state after 4th dosing of cagrilintide
From Pre-dose at Day 22 to Day 29
Cmax,ss: maximum observed concentration of total cagrilintide at steady state after 4th dosing of cagrilintide
From Pre-dose at Day 22 to Day 29
AUCss: area under the total cagrilintide concentration-time curve at steady state after 1st dosing of cagrilintide
From Pre-dose at Day 1 to Day 8
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Cagrilintide BEXPERIMENTALParticipants will receive cagrilintide B subcutaneously once weekly for 5 weeks.
Cagrilintide DEXPERIMENTALParticipants will receive cagrilintide D subcutaneously once weekly for 5 weeks.

Interventions

NameTypeDescription
Cagrilintide BDRUGCagrilintide B will be administered subcutaneously.
Cagrilintide DDRUGCagrilintide D will be administered subcutaneously.
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Eligibility Criteria

Age Range18 Years to 64 Years
SexALL
Healthy VolunteersNo
Study Sites1

Key Inclusion Criteria: * Age 18-64 years (both inclusive) at the time of signing informed consent. * Male or female (sex assigned at birth). * Body mass index (BMI) between 27.0 and 34.9 kilogram per meter square (kg/m\^2) (both inclusive) at screening. Overweight should be due to excess adipose t...

Countries:United States
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Recent Changes (Last 90 Days)

LOWAug 17, 2026NCT07605052lastUpdatePostDate: changed
LOWAug 17, 2026NCT07605052lastUpdatePostDate: changed
MEDIUMJul 9, 2026NCT07605052Status: NOT_YET_RECRUITING → ACTIVE_NOT_RECRUITING
MEDIUMJul 9, 2026NCT07605052Status: NOT_YET_RECRUITING → ACTIVE_NOT_RECRUITING

Frequently asked questions about Cagrilintide B

What is Cagrilintide B used for?

Cagrilintide B is an investigational small molecule being studied for the treatment of overweight and obesity. It is currently in Phase 1 clinical development, with an active clinical trial evaluating its blood levels in adults with excess body weight.

Who makes Cagrilintide B?

Cagrilintide B is being developed by Novo Nordisk A/S, a pharmaceutical company listed on the stock exchange under the ticker NVO. The company is conducting clinical trials to evaluate the drug's safety and pharmacokinetics in overweight and obese adults.

What phase is Cagrilintide B in?

Cagrilintide B is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The ongoing Phase 1 trial is active but not recruiting participants, with a planned enrollment of 50 adults.

What clinical trials is Cagrilintide B in?

Cagrilintide B is being studied in a Phase 1 clinical trial with the identifier NCT07605052. The trial, titled 'A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body Weight,' is active but not recruiting and is being conducted in the United States.

Is Cagrilintide B the same as Cagrilintide B and placebo semaglutide I?

Cagrilintide B is also known as Cagrilintide B and placebo semaglutide I. This alternative name may be used in clinical trial documentation to describe the study treatment regimen, which includes Cagrilintide B alongside a placebo for semaglutide.

How does Cagrilintide B work?

Cagrilintide B is a peptide-based small molecule, classified under the target class '-tide (peptide).' It is being investigated for its effects on weight management, though the specific molecular target has not been disclosed in available information.