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H5N1 VLP Vaccine

Phase 1

Pandemic Influenza | Monoclonal antibody | Infectious Disease |Novavax, Inc.|Last Updated: Jun 21, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment230
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00519389Safety, Reactogenicity and Immunogenicity of an H5N1 VLPPHASE1 COMPLETED 230Jul 1, 2007Nov 1, 2008Jun 21, 20131 United States
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Study Endpoints
Primary Endpoints
Safety and reactogenicity of H5N1 VLP Vaccine
6 months
Secondary Endpoints
Immunogenicity of H5N1 VLP Influenza vaccine
6 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Low dose H5N1 VLP VaccineEXPERIMENTAL -
Mid dose H5N1 VLP VaccineEXPERIMENTAL -
High dose H5N1 VLP VaccineEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
H5N1 VLP VaccineBIOLOGICALTwo doses - Day 0 \& Day 28
PlaceboBIOLOGICALTwo doses - Day 0 \& Day 28
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Eligibility Criteria
Age Range18 Years — 40 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Male or female 18 to 40 years of age at the time of the vaccination. 2. Subjects who the investigator believes can and will comply with the requirements of the protocol (e.g., return for follow-up visits and completion of the data collection tool). 3. Available by telephone. ...

Countries:United States
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