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A/H1N1 2009 Influenza VLP Vaccine

Phase 2

Seasonal Influenza | Monoclonal antibody | Infectious Disease |Novavax, Inc.|Last Updated: Apr 25, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment4,560
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01072799Safety and Immunogenicity of an A (H1N1) 2009 Influenza Virus-like Particle (VLP) VaccinePHASE2 COMPLETED 4,560Oct 1, 2009Mar 1, 2012Apr 25, 20121 Mexico
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Study Endpoints
Primary Endpoints
Safety and tolerability of two injections of A (H1N1) 2009 influenza VLP vaccine
35 days
Secondary Endpoints
Evaluation of immunogenicity of two injections of A (H1N1) 2009 influenza VLP vaccine by Hemagglutination Inhibition
35 days
Long-term Serious Adverse Events (SAEs) and Significant New Medical Conditions (SNMCs)
6 months post second dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Low dose H1N1EXPERIMENTAL -
Mid dose H1N1EXPERIMENTAL -
High dose H1N1EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
PlaceboBIOLOGICALTwo doses (Day 1 and Day 22); 0.5mL
A/H1N1 2009 Influenza VLP VaccineBIOLOGICALTwo doses (Day 1 \& Day 22); 0.5mL
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Eligibility Criteria
Age Range18 Years — 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Male or female 18-64 years of age at the time of the vaccination. 2. Informed consent must be obtained from the subject prior to beginning any study specific procedures indicating that they understand the purpose of this study and are willing to adhere to the procedures descr...

Countries:Mexico
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