Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Multiple administration of omeprazole Single administration of AB-106 · 1 trial · 1 indication
plasma drug peak concentration
area under the plasma drug concentration time curve from 0 to the last measurable drug concentration time point
Area under the plasma drug concentration time curve from 0 to infinity (if it can be calculated reliably)
| Arm | Type | Description |
|---|---|---|
| Omeprazole combined with AB-106 group | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| Multiple administration of omeprazole Single administration of AB-106 | DRUG | Take AB-106 capsule 400 mg orally on an empty stomach in the morning of the first day of the first cycle Take omeprazole magnesium enteric coated tablets 40mg once a day, 30 minutes before breakfast on days 1-4 of the second cycle. On the morning of the fifth day of the second cycle, the subjects will take omeprazole magnesium enteric coated tablets 40 mg, and AB-106 capsules 400 mg after an interval of 1 hour |
Inclusion Criteria: 1. Chinese male healthy subjects (health refers to the state without clinically relevant abnormalities confirmed by medical history, physical examination, vital signs, 12 lead ECG and clinical laboratory examination). 2. The age at the time of signing the informed consent was be...