Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
nexiguran ziclumeran · 1 trial · 20 indications
| Arm | Type | Description |
|---|---|---|
| nexiguran ziclumeran | EXPERIMENTAL | nexiguran ziclumeran 55 mg by single IV infusion |
| Normal Saline | PLACEBO_COMPARATOR | Placebo; Normal saline (0.9% NaCl) by single IV infusion |
| Name | Type | Description |
|---|---|---|
| nexiguran ziclumeran | BIOLOGICAL | nexiguran ziclumeran 55 mg by single IV infusion |
| Normal Saline as Placebo | DRUG | Normal saline (0.9% NaCl) by single IV infusion |
Inclusion Criteria: * Diagnosis of ATTRv-PN * Karnofsky Performance Status (KPS) ≥ 60 Exclusion Criteria: * Other causes of amyloidosis (amyloidosis caused by non-TTR protein) * Other known causes of sensorimotor or autonomic neuropathy * Diabetes mellitus * New York Heart Association Class III o...