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Mazindol

Phase 2

Narcolepsy With Cataplexy | Small molecule | Other |NewcelX Ltd.|Last Updated: Mar 13, 2023

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment52
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05055024An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With NarcolepsyPHASE2 COMPLETED 52Oct 26, 2021Jan 19, 2023Mar 13, 202322 United States
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Study Endpoints
Primary Endpoints
To evaluate the safety and tolerability of NLS-2 in adult subjects with narcolepsy type 1 (NT1) or narcolepsy type 2 (NT2)
24 weeks

Summaries of the number and percentage of subjects who experienced Treatment Emergent Adverse Events (TEAEs), TEAEs related to study drug, SAEs, or discontinued study drug or withdrew from the study due to an AE.

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
NLS-2 (mazindol extended release)EXPERIMENTALNLS-2 (mazindol extended release) administered once a day.
Interventions
NameTypeDescription
MazindolDRUGDrug: NLS-2
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites22

Inclusion Criteria: * The subject must complete all Study NLS-1021 study requirements and assessments up to Visit 6; * The subject is able, in the opinion of the Investigator, to receive NLS-2 for the 24-week Treatment Phase of this study; * Biological females of childbearing potential must agree t...

Countries:United States
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