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Neurocrine Biosciences, Inc.

NBIXFDA catalysts, PDUFA dates & pipeline intelligence
$146.38
▲ +0.47 · +0.32%

Financials

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52W LOW $122.1452W HIGH $186.12
Volume
831.12 K
Value Traded
153.70 M
Short % Float
6.42%
Days to Cover
4.5
+2.58%Week
+3.2%1 Month
-12.24%3 Month
+11.08%6 Month
+64.72%5 Year
+1,205.83%All Time

Cash Data

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Key Stats

Market Cap
14.88 B
EPS (TTM)
6.94
P/E Ratio
21.09
Ent. Value
14.40 B
Total Shares
101.69 M
Float Shares
100.42 M
Insiders
1.21%
Institutions
102.29%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 1 data readout
NBIP-'2118
Obesity
Phase 1Small MoleculesEndocrine System
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

NBIX Catalyst Timeline

Dated clinical, regulatory and corporate events for Neurocrine Biosciences, Inc.

Catalyst Timeline

Dated clinical, regulatory & corporate events for Neurocrine Biosciences, Inc.

1206Total events
13Upcoming
298Tier-1 (high impact)
2010 to 2027Coverage

Upcoming catalysts 2

T2Quarterly Update
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T1Topline Readout
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NBIP-'2118

Event history 50

●Poster PresentationValbenazineApprovedPresentation
Poster presentation of EQ-VAS clinically meaningful change analysis from KINECT-PRO and TD-4002 at AMCP Nexus 2026
tardive dyskinesiasource ↗
●Poster PresentationValbenazineApprovedPresentation
Presentation on real-world dosing trends and projections for valbenazine and deutetrabenazine XR in the U.S. at AMCP Nexus 2026
tardive dyskinesiasource ↗
●Poster PresentationPresentation
Presentation on anticholinergic polypharmacy among Medicare beneficiaries with and without tardive dyskinesia at AMCP Nexus 2026
tardive dyskinesiasource ↗
▲Product LaunchPost-Market
VYKAT XR commercially available to U.S. patients
hyperphagia in Prader-Willi syndromesource ↗
●PublicationPresentation
Publication in Orphanet Journal of Rare Diseases on hyperphagia in PWS
Prader-Willi syndrome hyperphagiasource ↗
●Trial InitiationNBI-1117567Trial
Neurocrine initiates Phase 2 study of NBI-1117567 in mild to moderate Alzheimer's disease
mild to moderate Alzheimer's diseasesource ↗
◆Poster PresentationCrinecerfontApprovedPresentation
2-Year CAHtalyst Adult cardiometabolic results for crinecerfont to be presented at Endocrine Nurses Society Annual Symposium 2026
classic congenital adrenal hyperplasiasource ↗
●RWE DataClinical Data
Real-world patient journey mapping data in classic CAH presented at Endocrine Nurses Society Annual Symposium 2026
classic congenital adrenal hyperplasiasource ↗
▲Poster PresentationCrinecerfontApprovedPresentation
2-Year CAHtalyst Pediatric results of crinecerfont presented at Endocrine Nurses Society Annual Symposium 2026
classic congenital adrenal hyperplasiasource ↗
▲IND ClearanceNBI-1117567IND
FDA IND Acceptance for Phase 2 study of NBI-1117567
Alzheimer's cognitionsource ↗
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Every PDUFA date, readout, approval and corporate move, tiered by market impact and updated daily.
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Past FDA Catalysts and PDUFA Decisions

How NBIX actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-10-16Crinecerfont (CRENESSITY) Phase 3 data presentation Phase 3
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
10
Drugs Scored
rNPV / MCap
Top Drug
Top 6%
Mid Cap
(rank 40 of 657)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Jun 2026; product lines: last four quarters to Jun 2026 (10-K and 10-Q))
ProductRevenuePrior periodChange
INGREZZA
CRENESSITY
VYKAT XR
Showing 27 of 47 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Osavampator Small moleculeNCT07196501Major Depressive DisorderPhase 3 RECRUITING 550Jul 1, 2028
NBI-1117568 Small moleculeNCT07288320Bipolar I DisorderPhase 2 RECRUITING 150Feb 1, 2028
NBI-1117567 Small moleculeNCT07832383Alzheimer's DiseasePhase 2 NOT YET_RECRUITING 135Jun 1, 2028
NBI-1117570 Small moleculeNCT07288333SchizophreniaPhase 2 RECRUITING 120Aug 1, 2027
NBI-1065890 Small moleculeNCT07365462Tardive DyskinesiaPhase 2 RECRUITING 100Mar 1, 2027
NBIP-01435 Small moleculeNCT07850739Congenital Adrenal HyperplasiaPhase 2 NOT YET_RECRUITING 36May 11, 2028
Crinecerfont Small moleculeMarketedNCT07187375Congenital Adrenal HyperplasiaPhase 3 ACTIVE NOT_RECRUITING 312Oct 4, 2029
NBI-1065845 Small moleculeNCT05203341Major Depressive DisorderPhase 3 COMPLETED 1,633Feb 21, 2024
NBI-1070770 Small moleculeCompletedNCT06267846Major Depressive DisorderPhase 2 COMPLETED 73Sep 11, 2025
NBI-1117568 Small moleculeNCT05545111SchizophreniaPhase 3 COMPLETED 1,938Jul 10, 2024
VY-AADC01 Monoclonal antibodyCompletedNCT01973543Parkinson's DiseasePhase 1 COMPLETED 29Jan 24, 2020
NBI-827104 Small moleculeCompletedNCT04625101Epileptic EncephalopathyPhase 2 COMPLETED 24Oct 11, 2022
NBI-827104 Small moleculeCompletedNCT04880616Essential TremorPhase 2 COMPLETED 31Jun 8, 2022
Chronocort Small moleculeCompletedNCT03019614Congenital Adrenal HyperplasiaPhase 3 COMPLETED 303Apr 1, 2010
Chronocort Small moleculeCompletedNCT05222152Primary Adrenal InsufficiencyPhase 2 COMPLETED 58Oct 18, 2023
Valbenazine Small moleculeMarketedNCT05110157SchizophreniaPhase 3 COMPLETED 442Feb 18, 2025
Valbenazine Small moleculeMarketedNCT04400331Chorea, HuntingtonPhase 3 COMPLETED 289Nov 5, 2025
NBI-98854 Small moleculeMarketedNCT01393600Tardive DyskinesiaPhase 3 COMPLETED 659Feb 1, 2012
Valbenazine Small moleculeMarketedNCT02736955Tardive DyskinesiaPhase 3 COMPLETED 161Jun 30, 2017
Valbenazine Small moleculeMarketedNCT05206513DyskinesiaPhase 3 COMPLETED 86Mar 31, 2026
Crinecerfont Small moleculeMarketedNCT04045145CAH - Congenital Adrenal HyperplasiaPhase 2 COMPLETED 8Jul 2, 2021
NBI-74788 Small moleculeMarketedNCT03525886CAH - Congenital Adrenal HyperplasiaPhase 2 COMPLETED 18Apr 7, 2020
NBI-98854 Small moleculeMarketedNCT02256475Tourette SyndromePhase 2 COMPLETED 258Dec 1, 2015
Valbenazine Small moleculeMarketedNCT02879578Tourette SyndromePhase 2 COMPLETED 367Nov 1, 2017
NBI-98854 Small moleculeMarketedNCT01916993Safety, Tolerability, and PK of NBI-98854 in Hepatically Impaired SubjectsPhase 1 COMPLETED 24Dec 1, 2013
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Clinical Trial Results

Readouts, endpoints and source filings for every NBIX program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
VYKAT XR Prader-Willi syndromePhase 32026-06-156.2 points at Year 1; 6.5 points at Year 2; 6.2 points at Year 3; -2.5 in anxiety; -2.4 in rigidity/irritability; -2.3 in compulsivity; -2.1 in aggressive behaviors; -1.5 in disordered thinking; -1.1 in depressionRead MoreSoleno Therapeutics Presents New VYKAT® XR (diazoxide choline) Data at ENDO 2026 Demonstrating Meaningful and Durable Improvements in Hyperphagia and Behavioral Symptoms in Prader-Willi Syndrome Following Randomized Withdrawal Period Soleno Therapeutics, a Neurocrine Biosciences (Nasdaq: NBIX) company, today announced late-breaking data at ENDO 2026 showing that resuming treatment ...Read More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
Boyer David W.Officer (Chief Corp. Affairs Officer)Sell -826 8,722 held$157.45 09/14/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
RTW INVESTMENTS, LP 1.8 % (28.6 %) 213.69 M 1.27 M 19.38% ( 205.85 K)
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NBIX Institutional Ownership Trends

NBIX Short Interest

Shares sold short, counted twice a month.

6.42%
Short % of Float
of tradable shares sold short
6.4M
Shares Sold Short
+10.2% vs prior count
4.5 Moderate
Days to Cover
trading days of normal volume to buy every short share back
1.4M
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-11-20
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

CallsPutsLog scale
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Competitive positioning

How NBIX ranks across every disease it competes in

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See how NBIX ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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NBIX News

NBIX
Oct 26, 2026
NBIXConferences/Events
▲ +0.3%today

Neurocrine Biosciences Presents New Analysis Establishing Benchmark for Clinically Meaningful Change in Overall Health Reported by Patients with Tardive Dyskinesia

Neurocrine Biosciences announced a new analysis establishing a 6-point increase on the EQ Visual Analogue Scale as a benchmark for clinically meaningful change in patients with tardive dyskinesia treated with INGREZZA. This finding contextualizes a mean 13.1-point improvement observed in the KINECT-PRO study. The results will be presented at the Academy of Managed Care Pharmacy Nexus 2026 conference.

Read more →
NBIX
Oct 22, 2026
NBIXGeneral

Neurocrine Biosciences Announces Publication in Orphanet Journal of Rare Diseases Advancing Understanding of Hyperphagia in Prader-Willi Syndrome

Neurocrine Biosciences announced a publication in the Orphanet Journal of Rare Diseases, detailing expert insights on hyperphagia in Prader-Willi syndrome (PWS). The manuscript emphasizes the complexity of hyperphagia and the importance of integrated care management. VYKAT XR, an FDA-approved treatment, is noted as a significant advancement in managing this condition.

Read more →
NBIX
Oct 20, 2026
NBIXPhases

Neurocrine Biosciences Initiates Phase 2 Clinical Study Evaluating NBI-'567 in Adults with Alzheimer's Disease

Neurocrine Biosciences has launched a Phase 2 clinical study for NBI-'567, an investigational drug aimed at treating cognitive impairment in adults with mild to moderate Alzheimer's disease. The study will assess the drug's efficacy, safety, and pharmacokinetics over a 12-week period. This initiative reflects Neurocrine's commitment to developing innovative treatments for Alzheimer's and other neurological conditions.

Read more →
NBIX
Oct 16, 2026
NBIXConferences/Events

Neurocrine Biosciences Presents Real-World Evidence Mapping the Lifelong, Evolving Impact of Classic Congenital Adrenal Hyperplasia

Neurocrine Biosciences presented new real-world data on classic congenital adrenal hyperplasia (CAH) at the Endocrine Nurses Society Annual Symposium 2026. The analysis utilized patient records to illustrate the diverse challenges faced by CAH patients throughout their lives. It emphasized the importance of understanding patient experiences to enhance care and support strategies.

Read more →
NBIX
Oct 12, 2026
NBIXConferences/Events

Neurocrine Biosciences Announces Conference Call and Webcast of Third Quarter 2026 Financial Results

Neurocrine Biosciences has announced a conference call and webcast for its third quarter 2026 financial results, scheduled for November 2, 2026. The press release will precede the call, providing financial insights to investors. The company continues to focus on developing treatments for various neurological and psychiatric disorders, showcasing its commitment to patient care.

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NBIX
Sep 30, 2026
NBIXConferences/Events

Neurocrine Biosciences to Present Research Advancing Understanding of Prader-Willi Syndrome and Real-World Experience with VYKAT® XR (diazoxide choline) at Foundation for Prader-Willi Research Symposium & Family Conference

Neurocrine Biosciences will present research on Prader-Willi syndrome and VYKAT XR at the FPWR 2026 Annual Research Symposium. The studies include the PWS-VISTA observational study, which focuses on real-world evidence of VYKAT XR, and the BRAVE-PWS study, which captures caregiver experiences. The findings aim to deepen understanding of PWS and improve treatment approaches.

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NBIX
Sep 28, 2026
NBIXGeneral

Neurocrine Biosciences Appoints Eiry W. Roberts, M.D., as Chief Medical Officer

Neurocrine Biosciences has appointed Eiry W. Roberts, M.D., as Chief Medical Officer, effective immediately. Dr. Roberts previously held this role from 2018 to 2025 and has been a Strategic Advisor since. Her return is expected to provide continuity as the company advances its late-stage clinical programs and prepares for significant milestones.

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NBIX
Sep 2, 2026
NBIXConferences/Events

Neurocrine Biosciences to Present at Upcoming Investor Conferences in September

Neurocrine Biosciences, Inc. announced its participation in several investor conferences in September 2026. The events include the Wells Fargo 21st Annual Healthcare Conference, Cantor Global Healthcare Conference 2026, and Morgan Stanley 24th Annual Global Healthcare Conference. Executives will engage in fireside chats, and webcasts will be available for those unable to attend live.

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NBIX
Aug 26, 2026
NBIXFDA Updates

Nxera Pharma’s Partner Neurocrine Biosciences Receives IND Acceptance from the FDA for Phase 2 Study of NBI-1117567 for Alzheimer's Cognition

Neurocrine Biosciences has received IND acceptance from the FDA for NBI-1117567, an investigational drug for Alzheimer's cognition. Nxera Pharma will receive a $10 million milestone payment as part of their collaboration. NBI-1117567 is the third compound from Nxera's muscarinic agonist portfolio to advance to Phase 2, indicating progress in addressing Alzheimer's disease.

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NBIX
Aug 12, 2026
NBIXPhases

Neurocrine Biosciences Announces Publication of KINECT-PRO™ Findings Demonstrating INGREZZA® (valbenazine) Capsules Improved Patient-Reported Quality of Life and Daily Functioning for People Living with Tardive Dyskinesia

Neurocrine Biosciences announced the publication of KINECT-PRO™ findings, showing that INGREZZA® (valbenazine) significantly improves patient-reported quality of life and functionality in individuals with tardive dyskinesia (TD). The Phase 4 study revealed that 58% of participants achieved symptomatic remission by Week 24, with improvements noted across various severity levels. The results underscore the treatment's effectiveness in enhancing daily functioning and reducing movement severity.

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NBIX
Aug 7, 2026
NBIXPhases

Neurocrine Biosciences Announces Initiation of Phase 1 Clinical Study Evaluating NBIP-'1968, a GLP-1/GIP/Glucagon Receptor Triple Agonist

Neurocrine Biosciences has initiated a Phase 1 clinical study for NBIP-'1968, a triple agonist targeting GLP-1, GIP, and glucagon receptors, aimed at treating obesity. This study will assess the safety and tolerability of the drug in adult participants with varying body mass indices. The development of NBIP-'1968 is part of a broader strategy to expand Neurocrine's obesity treatment options.

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NBIX
Jul 30, 2026
NBIXGeneral
▼ -10.1%on this news

Neurocrine Biosciences Reports Second-Quarter 2026 Financial Results

Neurocrine Biosciences reported a strong second-quarter performance for 2026, with total revenues increasing by 39% year-over-year to $959 million. The company raised its net sales guidance for INGREZZA, reflecting robust demand and prescription growth. Additionally, the acquisition of Soleno Therapeutics is expected to strengthen its position in the market. Positive clinical trial results for CRENESSITY further bolster the company's outlook.

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NBIX
Jul 23, 2026
NBIXGeneral

Neurocrine Biosciences Announces Key Leadership Hiring, Promotions

Neurocrine Biosciences has announced the appointment of three Senior Vice Presidents to enhance its leadership as it enters a new growth phase. Bret Paulson, David Bradfute, and Aaron Vosburgh will take on key roles in market access, intellectual property, and finance, respectively. These changes aim to support the company's expanding commercial portfolio and neuroscience pipeline.

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NBIX
Jul 21, 2026
NBIXGeneral

Neurocrine Biosciences Appoints Samir Siddhanti Chief Business Officer

Neurocrine Biosciences has appointed Samir Siddhanti as Chief Business Officer, where he will lead the company's growth strategy and oversee business development. Siddhanti has been with Neurocrine since 2017, playing a key role in strategic partnerships and the recent acquisition of Soleno Therapeutics. His leadership is expected to enhance the company's pipeline and drive future growth.

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NBIX
Jul 9, 2026
NBIXConferences/Events

Neurocrine Biosciences Announces Conference Call and Webcast of Second Quarter 2026 Financial Results

Neurocrine Biosciences has announced a conference call and webcast to discuss its second quarter 2026 financial results. Scheduled for July 30, 2026, the call will begin at 1:30 p.m. PT. The company aims to provide updates on its financial performance and ongoing projects, showcasing its commitment to addressing neurological and psychiatric disorders.

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NBIX
Jul 1, 2026
NBIXPhases

Neurocrine Biosciences Initiates Phase 2 Study of Crinecerfont in Pediatric Patients Under 4 Years Old with Classic Congenital Adrenal Hyperplasia

Neurocrine Biosciences has launched a Phase 2 clinical trial for crinecerfont, targeting children under 4 years with classic congenital adrenal hyperplasia (CAH). The study aims to evaluate the drug's safety and tolerability in a vulnerable population often reliant on high glucocorticoid doses. This initiative reflects the company's commitment to improving treatment options for young patients with CAH.

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NBIX
Jun 15, 2026
NBIXGeneral

Neurocrine Biosciences Presents First Retrospective Case Series of CRENESSITY® (crinecerfont) in Patients with Classic Congenital Adrenal Hyperplasia Due to 11β‑Hydroxylase Deficiency at ENDO 2026

Neurocrine Biosciences presented a retrospective case series at ENDO 2026, showcasing the effects of CRENESSITY (crinecerfont) in patients with classic congenital adrenal hyperplasia due to 11β-hydroxylase deficiency. The study revealed substantial reductions in adrenal hormone levels and glucocorticoid doses among patients. This case series provides preliminary insights into the treatment of this rare condition, emphasizing the need for further research.

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NBIX
Jun 15, 2026
NBIXPhases

Neurocrine Biosciences Presents New Two-Year CRENESSITY® (crinecerfont) Data Demonstrating Improved Growth Measures in Pediatric Patients with Classic Congenital Adrenal Hyperplasia at ENDO 2026

Neurocrine Biosciences presented two-year data on CRENESSITY (crinecerfont) at ENDO 2026, showing positive growth outcomes in pediatric patients with classic congenital adrenal hyperplasia (CAH). The study indicated slowed bone age progression and improved predicted adult height. Caregiver surveys revealed universal satisfaction and optimism regarding the treatment's impact on children's quality of life.

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NBIX
Jun 15, 2026
NBIXPhases

Neurocrine Biosciences Presents New Two-Year CRENESSITY® (crinecerfont) Data Demonstrating Improvements in Cardiometabolic Outcomes in Adults with Classic Congenital Adrenal Hyperplasia at ENDO 2026

Neurocrine Biosciences presented new data from the Phase 3 CAHtalyst Adult study at ENDO 2026, showing that CRENESSITY (crinecerfont) significantly improved cardiometabolic outcomes and reduced glucocorticoid doses in adults with classic congenital adrenal hyperplasia (CAH). Over two years, participants experienced weight loss, improved insulin resistance, and enhanced bone health. Patient surveys indicated high satisfaction and improved quality of life.

Read more →
NBIX
Jun 15, 2026
NBIXConferences/Events

Soleno Therapeutics Presents New VYKAT® XR (diazoxide choline) Data at ENDO 2026 Demonstrating Meaningful and Durable Improvements in Hyperphagia and Behavioral Symptoms in Prader-Willi Syndrome Following Randomized Withdrawal Period

Soleno Therapeutics presented data showing VYKAT XR improved hyperphagia and behavioral symptoms in Prader-Willi syndrome patients after a withdrawal period. Participants who resumed treatment demonstrated durable benefits continuing through two years. The drug also showed sustained improvements compared to natural history data for up to three years. These results reinforce the long-term efficacy of the therapy for this condition.

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About Neurocrine Biosciences, Inc.

San Diego, CA 2,500 employees neurocrine.com
Headquarters6027 EDGEWOOD BEND COURT, SAN DIEGO, CA, 92130
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