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NBI-6024

Phase 1

Type 1 Diabetes Mellitus | Small molecule | Metabolic |Neurocrine Biosciences, Inc.|Last Updated: Apr 1, 2009

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment188

FDA Designations

No designations recorded

Clinical trial landscape

NBI-6024 · 1 trial · 1 indication

Phase 1 1
NCT00873561A Study to Evaluate NBI-6024 in Adult and Adolescent Patients With New Onset of Type 1 Diabetes MellitusType 1 Diabetes Mellitus
COMPLETED188 Analytics
PHASE1COMPLETED
A Study to Evaluate NBI-6024 in Adult and Adolescent Patients With New Onset of Type 1 Diabetes Mellitus
Type 1 Diabetes MellitusUnlock trial analytics

Study Endpoints

Primary Endpoints

To assess the effect of repeated administrations of NBI-6024 on endogenous insulin production as measured by C-peptide levels in adult and adolescent patients with new onset type 1 diabetes mellitus
monthly assessments, up to 24 months (end of study)

Secondary Endpoints

To examine the effects of repeated administrations of NBI-6024 on insulin usage, glycemic control, and immune function (immunodynamics and pharmacodynamics) To examine the safety and tolerability of repeated administrations of NBI-6024
monthly assessments, up to 24 months (end of study)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
1 ExperimentalACTIVE_COMPARATORNBI-6024 0.1 mg
2 ExperimentalACTIVE_COMPARATORNBI-6024 0.5 mg
3 ExperimentalACTIVE_COMPARATORNBI-6024 1 mg
4 placeboNO_INTERVENTIONPlacebo injection

Interventions

NameTypeDescription
NBI-6024DRUG0.1, 0.5 or 1 mg NBI-6024 First 3 doses every 2 weeks. Remaining doses given monthly. Total duration of dosing 24 months. Placebo controlled.
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Eligibility Criteria

Age Range10 Years to 35 Years
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * Male or female between the age of 12 and 35 years, inclusive (changed to between the age of 10 and 35 years, inclusive, under Amendment 2) * If female of childbearing potential, patient must use an acceptable method of birth control prior to and for 30 days post study * Adult ...

Countries:CanadaCzechiaFinlandFranceGermanySouth AfricaSpainUnited Kingdom
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Frequently asked questions about NBI-6024

What is NBI-6024 used for?

NBI-6024 is an investigational small molecule being developed for the treatment of Type 1 Diabetes Mellitus. It is intended for adult and adolescent patients with new onset of the disease. The drug is currently in Phase 1 clinical development and has not been approved by regulatory authorities.

Who makes NBI-6024?

NBI-6024 is being developed by Neurocrine Biosciences, Inc., a biopharmaceutical company traded on NASDAQ under the ticker symbol NBIX. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational therapy for Type 1 Diabetes Mellitus.

What phase is NBI-6024 in?

NBI-6024 is in Phase 1 clinical development. One Phase 1 trial has been completed, involving 188 participants. The drug remains investigational and has not received FDA approval. It is being studied in adult and adolescent patients with new onset of Type 1 Diabetes Mellitus.

What clinical trials is NBI-6024 in?

NBI-6024 has one completed clinical trial, registered as NCT00873561. This Phase 1 study evaluated the drug in adult and adolescent patients with new onset of Type 1 Diabetes Mellitus. The trial was randomized, double-blind, and active-controlled, enrolling 188 participants across multiple countries including Canada, Czechia, Finland, France, Germany, South Africa, Spain, and the United Kingdom.

Is NBI-6024 FDA approved?

No, NBI-6024 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. A completed Phase 1 trial has evaluated its use in Type 1 Diabetes Mellitus, but the drug has not yet received regulatory approval for any indication.