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Drug Omega 3

Phase 1

Hypertriglyceridemia | Small molecule | Other |Matinas Biopharma Holdings, Inc.|Last Updated: Oct 12, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02310022A PK and PD Study of Two Formulations of Omega-3 One Gram CapsulesPHASE1 COMPLETED 48Nov 1, 2014Aug 1, 2016Oct 12, 20201 Canada
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Study Endpoints
Primary Endpoints
Bioavailability comparison after single and multiple doses over a 24 hour period at day 1 and day 14
14 Days

Area under the plasma concentration curve versus time curve (AUC0-tau) versus time curve (AUC0-tau) for both treatments measured over the 24 hour period on day 1 and day 14 \[ Time Frame: 14 days \]

Secondary Endpoints
Comparison of baseline changes of triglycerides and other related lipid protein parameter levels over 14 days
14 Days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Drug Omega 3EXPERIMENTAL4g (4 capsules) once a day, administered with food Other name MAT9001
Drug Omega 3 ComparatorACTIVE_COMPARATOR4g (4 capsules) once a day, administered with food Other name Omega 3 Active Comparator
Interventions
NameTypeDescription
Drug Omega 3DRUG4 g (4 capsules) once a day, administered with food
Drug Omega-3 ComparatorDRUG4 g (4 capsules) once a day, administered with food
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Eligibility Criteria
Age Range18 Years — 70 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: Subjects must fulfil all of the following inclusion criteria to be eligible for participation in the study, unless otherwise specified: 1. Adult male or female subject, 18-70 years of age, inclusive. 2. Light- or non-smoking, male and female subjects, 18 to 70 years of age. Not...

Countries:Canada
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