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testosterone undecanoate

Phase 2

Hypogonadism | Small molecule | Endocrine |Merck & Company, Inc.|Last Updated: Apr 16, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment322
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00434824Effects of Andriol Testocaps in Symptomatic Late-Onset Hypogonadism (43203)PHASE2 COMPLETED 322Nov 1, 2001Jul 1, 2004Apr 16, 2015 -
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Study Endpoints
Primary Endpoints
Change from baseline on the total score of the AMS rating scale
Month 6
Secondary Endpoints
Effects on AMS rating scale, bone mineral density, bone markers, muscle and fat mass, muscle strength, hematocrit, endocrine parameters, PSA, IPSS and lipids
Month 12
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Arm 1ACTIVE_COMPARATOROral testosterone undecanoate (Andriol)
Arm 2PLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
Oral testosterone undecanoate (Andriol)DRUGtreatment for 12 months with oral TU 80 mg/d, oral TU 160 mg/d or oral TU 240 mg/d in divided doses
PlaceboDRUGtreatment for 12 months with placebo in divided doses
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Eligibility Criteria
Age Range50 Years — N/A
SexMALE
Healthy VolunteersNo

Inclusion Criteria: * Subjects were at least 50 years of age * A body mass index (BMI) between 18 and 34 kg/m\^2 * Symptoms of androgen deficiency (as indicated by a positive Androgen Deficiency in Aging Males (ADAM) questionnaire) * Calculated free testosterone measurement of \<0.26 nmol/L in the ...

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