Recent Updates
Recently added Catalysts

TR-701 di- salt

Phase 1

Undisclosed | Small molecule | Other |Merck & Company, Inc.|Trials Updated: May 3, 2016

TR-701 di- salt target and mechanism

ModalitySmall molecule

Also known as TR-701 di-sodium phosphate salt

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

TR-701 di- salt clinical trials

TR-701 di- salt · 1 trial · 1 indication

Phase 1 1
NCT00876655Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid PhosphateHealthy
COMPLETED12 Analytics
PHASE1COMPLETED
Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid Phosphate
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

To evaluate the pharmacokinetics and relative bioavailability of TR-701 free acid phosphate powder in capsule formulation compared to di-sodium phosphate salt formulated capsule after single doses in normal healthy adult subjects
4 days

Secondary Endpoints

To determine the safety and tolerability of 2 different TR-701 oral formulations (free acid phosphate powder in capsule and di-sodium phosphate salt formulated capsule) after single doses in normal healthy adult
4 days
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
free acidEXPERIMENTALTR-701 free acid phosphate powder in capsule formulation (equivalent to 150 mg TR-700)
di-sodium phosphate saltEXPERIMENTALOne 200 mg capsule of TR-701 di-sodium phosphate salt (equivalent to 150 mg TR-700)

Interventions

NameTypeDescription
TR-701 di-sodium phosphate saltDRUGOne 200 mg capsule of TR-701 di-sodium phosphate salt (equivalent to 150 mg TR-700)
TR-701 free acid phosphateDRUGOne 182 mg capsule of TR-701 free acid phosphate (equivalent to 150 mg TR-700)
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, and vital signs; * Females will be non-pregnant, non-lactating, and either postmenopausal for at least 1 year, surgically sterile for at least 90 days, or ...

Countries:United States
Unlock Eligibility Criteria

Frequently asked questions about TR-701 di- salt

What is TR-701 di- salt?

TR-701 di- salt is an investigational small molecule developed by Merck & Company, Inc. (MRK). It is also known as TR-701 di-sodium phosphate salt. The compound has been studied in a Phase 1 clinical trial and is not approved for any indication.

Who makes TR-701 di- salt?

TR-701 di- salt is being developed by Merck & Company, Inc., which trades under the ticker MRK. Merck is the sponsor of the clinical program for this investigational small molecule.

What phase is TR-701 di- salt in?

TR-701 di- salt is in Phase 1 clinical development. One Phase 1 trial has been completed, and no active trials are currently listed. The drug remains investigational and has not been approved by the FDA for any use.

What clinical trials is TR-701 di- salt in?

TR-701 di- salt has been evaluated in one completed Phase 1 trial, NCT00876655, titled an Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid Phosphate. The trial enrolled 12 healthy adult volunteers in the United States and was randomized and controlled.

Is TR-701 di- salt the same as TR-701 di-sodium phosphate salt?

Yes, TR-701 di- salt is also known as TR-701 di-sodium phosphate salt. Both names refer to the same investigational small molecule developed by Merck & Company, Inc. (MRK).