Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
TR-700 · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| Pilot study | EXPERIMENTAL | 3 subjects, open lable, microdialysis single dose. |
| Main Study | EXPERIMENTAL | 12 subjects, open label, single dose of 600 mg. |
| Name | Type | Description |
|---|---|---|
| TR-700 (active moiety) | DRUG | A TR-700 solution will be locally administered via a microdialysis probe into the skeletal muscle and subcutanous tissue (just under the skin) at a concentration of approximately 2 µg/mL at a flow rate of 1.5 µL/min for 60 minutes for a total maximum dose of 0.36 µg (0.18 µg per probe). |
| TR-701 (pro-drug) | DRUG | Each subject enrolled in the Main study will receive a single oral dose of 600mg TR-701 |
Inclusion Criteria: * Body mass index of 20 to 29 kg/m2 * Agree not to consume any products containing tobacco, alcohol, quinine, grapefruit, caffeine, or high levels of tyramine * Agree not to use any other medication * Female subjects must be postmenopausal (for at least 6 months), surgically ste...
TR-700 is an investigational small molecule being studied in healthy volunteers. It is currently in Phase 1 clinical development, with one completed trial involving 15 participants. The drug is not approved and remains under investigation.
TR-700 is being developed by Merck & Company, Inc., which trades under the ticker symbol MRK. The company is conducting clinical research on this investigational small molecule.
TR-700 is in Phase 1 clinical development. One Phase 1 trial has been completed, and the drug remains investigational. It has not been approved for any use.
TR-700 has one completed clinical trial, NCT00666601, titled 'Microdialysis and Pharmacokinetic Study of TR-701'. This Phase 1 study enrolled 15 healthy volunteers in the United States and was completed.
TR-700 is related to TR-701, as indicated by the clinical trial title 'Microdialysis and Pharmacokinetic Study of TR-701'. The trial studies TR-700, and the connection between the two compounds is noted in the study name.