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Synthetic GLP-1 dissolved in 0.9% saline

Phase 1

Sodium Excretion by Urination | Small molecule | Other |Merck & Company, Inc.|Trials Updated: Dec 14, 2015

Success Probability

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Market & Valuation

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Trial Design

ACTIVE_CONTROLLED
Total Trials1
Total Enrollment15

FDA Designations

No designations recorded

Synthetic GLP-1 dissolved in 0.9% saline clinical trials

Synthetic GLP-1 dissolved in 0.9% saline · 1 trial · 1 indication

Early Phase 1 1
NCT02130778Natriuretic Effect of GLP-1in Healthy Non Obese SubjectsSodium Excretion by Urination
COMPLETED15 Analytics
EARLY_PHASE1COMPLETED
Natriuretic Effect of GLP-1in Healthy Non Obese Subjects
Sodium Excretion by Urination
NCT0213077815
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Study Endpoints

Primary Endpoints

Evidence of the positive effect on natriuresis (level of sodium in urin sample) following the of GLP1 infusion
Within the 10 minutes after the infusion synthetic GLP-1 (1.5 pmol/kg/min) dissolved in 500 ml 0.9% saline
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingSINGLE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Saline infusionACTIVE_COMPARATORinfusion of saline
Saline infusion with GLP1ACTIVE_COMPARATORinfusion of saline with GLP1

Interventions

NameTypeDescription
Synthetic GLP-1 (1.5 pmol/kg/min) dissolved in 500 ml 0.9% salineDRUGinfusion of synthetic GLP-1 (1.5 pmol/kg/min) saline
500 ml 0.9% salineOTHERinfusion of saline
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Eligibility Criteria

Age Range18 Years to 70 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: Inclusion criteria: * Participant is ≥18 and ≤70 years of age on day of signing informed consent * Participant is a male, or a female who is unlikely to conceive, as indicated by at least one "yes" answer to the following questions: * Patient is a surgically sterilized femal...

Countries:Croatia
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