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RotaTeq- Rotavirus Vaccine, Live, Pentavalent

Phase 3

Vomiting | Vaccine | Infectious Disease |Merck & Company, Inc.|Last Updated: Apr 13, 2017

Target and mechanism

ModalityVaccine

Also known as RotaTeq™ - Rotavirus Vaccine, Live, Oral, Pentavalent

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment7,504

FDA Designations

No designations recorded

Clinical trial landscape

RotaTeq- Rotavirus Vaccine, Live, Pentavalent · 1 trial · 3 indications

Phase 3 1
NCT00362648Developing World Study for RotaTeq™ (V260-015)(COMPLETED)Vomiting
COMPLETED7,504 Analytics
PHASE3COMPLETED
Developing World Study for RotaTeq™ (V260-015)(COMPLETED)
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Study Endpoints

Primary Endpoints

Occurrence of Severe Clinical Rotavirus Disease Caused by Any Rotavirus Serotype More Than 14 Days Following the Third Dose
At least 14 days following the third vaccination

Secondary Endpoints

Africa - Serum Anti-rotavirus IgA Responses and Serum Neutralizing Antibody (SNA) Responses Against Rotavirus Serotypes G1, G2, G3, G4, and P1A[8]
14 days following the 3rd vaccination
Asia - Serum Anti-rotavirus IgA Responses and Serum Neutralizing Antibody (SNA) Responses Against Rotavirus Serotypes G1, G2, G3, G4, and P1A[8]
14 days following the 3rd vaccination
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
1EXPERIMENTALRotaTeq™
2PLACEBO_COMPARATORPlacebo

Interventions

NameTypeDescription
RotaTeq™ - Rotavirus Vaccine, Live, Oral, PentavalentBIOLOGICAL2.0 mL oral dose of RotaTeq™. 14 week treatment period
Comparator: PlaceboBIOLOGICALArm 2: Placebo. 14 week treatment period
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Eligibility Criteria

Age Range4 Weeks to 12 Weeks
SexALL
Healthy VolunteersYes

Inclusion Criteria: * Age 4 weeks through 12 weeks at Dose 1 * Parent able to understand study procedures and give consent Exclusion Criteria: * Clinical evidence of active gastrointestinal disease * Subjects who are currently or expected to participate in other studies of investigational product...

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Frequently asked questions about RotaTeq- Rotavirus Vaccine, Live, Pentavalent

What is RotaTeq used for?

RotaTeq is a vaccine studied for the prevention of rotavirus-related illness, including vomiting, diarrhea, and fever. It is an infectious disease vaccine developed by Merck. The clinical program evaluated it in healthy infants, with the primary study enrolling 7,504 participants.

Who makes RotaTeq?

RotaTeq is developed by Merck & Company, Inc., which trades under the ticker MRK. Merck sponsored the pentavalent live oral rotavirus vaccine and ran its clinical development program, including the Phase 3 study conducted in developing world settings.

What phase is RotaTeq in?

RotaTeq has been evaluated in Phase 3 clinical development. Its single registered trial, NCT00362648, was a Phase 3 study that has been completed. The program included 7,504 enrolled participants, and no trials are currently listed as active.

What clinical trials is RotaTeq in?

RotaTeq was studied in the Phase 3 trial NCT00362648, titled Developing World Study for RotaTeq (V260-015). The trial enrolled 7,504 healthy volunteers aged 4 weeks and older, was randomized, double blind, and placebo controlled, and it is now completed.

Is RotaTeq the same as Rotavirus Vaccine, Live, Oral, Pentavalent?

Yes. RotaTeq is also known as Rotavirus Vaccine, Live, Oral, Pentavalent, sometimes written with the trademark symbol as RotaTeq. These names refer to the same Merck pentavalent live oral rotavirus vaccine, so searches under either name point to the same product.

How was the RotaTeq Phase 3 trial designed?

The RotaTeq Phase 3 trial NCT00362648 was a randomized, double blind, placebo controlled study enrolling 7,504 healthy volunteers. Participants were at least 4 weeks old and of any sex, and the study covered vomiting, diarrhea, and fever. It has been completed.