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MK0991, caspofungin

Phase 3

Fungal Infection | Small molecule | Infectious Disease |Merck & Company, Inc.|Trials Updated: Feb 23, 2017

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials3
Total Enrollment234

FDA Designations

No designations recorded

MK0991, caspofungin clinical trials

MK0991, caspofungin · 3 trials · 3 indications

Phase 3 1Phase 2 2
NCT00548080Evaluate the Safety and Efficacy of Caspofungin Acetate as Empirical Therapy in Chinese Adults With Persistent Fever and Neutropenia (0991-055)Fungal Infection
COMPLETED131 Analytics
PHASE3COMPLETED
Evaluate the Safety and Efficacy of Caspofungin Acetate as Empirical Therapy in Chinese Adults With Persistent Fever and Neutropenia (0991-055)
Fungal InfectionUnlock trial analytics

Study Endpoints

Primary Endpoints

The proportion of caspofungin-treated patients with SAE
Favorable overall response rate
Tolerability.

Secondary Endpoints

The proportion of caspofungin-treated patients with a favorable efficacy response at the end of caspofungin study therapy
Favorable overall response rate on Day 10 of caspofungin therapy
Occurance of relapse during the 12 week follow-up period following the completion of all antifungal therapy
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
MK0991, caspofungin acetate / Duration of Treatment:DRUG -
MK0991, caspofungin acetate/Duration of Treatment: variableDRUG -
MK0991, caspofungin acetateDRUG -
Comparator: amphotericin BDRUG -
Comparator: lipid formulation of amphotericin B and/or azoleDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Patient has had an absolute neutrophil count \< 500/mm3 for at least 96 hours (the patient must not be expected to recover from neutropenia in the next 48 hours), and has received at least 96 hours of parenteral broad spectrum systemic antibacterial therapy preceding study ent...

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Competitive Landscape -Fungal Infections 21 trials (matched to "Fungal Infection")

Top 1 of 6 competitors

CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK1PHASE2Posaconazole
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Frequently asked questions about MK0991, caspofungin

What is MK0991 used for?

MK0991 is an investigational small molecule being studied for the treatment of aspergillosis, a fungal infection. It is currently in Phase 2 clinical development and has been evaluated in combination with standard antifungal agents for salvage therapy of invasive aspergillosis.

Who is developing MK0991?

MK0991 is being developed by Merck & Company, Inc., which trades on the New York Stock Exchange under the ticker symbol MRK. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with aspergillosis.

What phase is MK0991 in?

MK0991 is in Phase 2 clinical development for aspergillosis. It is an investigational drug, meaning it has not yet been approved by regulatory authorities and is still undergoing clinical evaluation to determine its safety and effectiveness.

What clinical trials is MK0991 in?

MK0991 has been studied in a completed Phase 2 clinical trial with the identifier NCT00076869. This trial evaluated MK0991 in combination with standard antifungal agents for the treatment of salvage invasive aspergillosis and enrolled 55 participants aged 16 years and older.

Is MK0991 the same as caspofungin?

Yes, MK0991 is also known as caspofungin. Both names refer to the same investigational drug being developed by Merck & Company, Inc. for the treatment of aspergillosis. The drug is currently in Phase 2 clinical trials.