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MK0991, caspofungin

Phase 2

Aspergillosis | Small molecule | Other |Merck & Company, Inc.|Last Updated: Jan 13, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment55
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00076869MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037)PHASE2 COMPLETED 55Jan 1, 2003Aug 1, 2005Jan 13, 2015 -
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Study Endpoints
Primary Endpoints
Tolerability.
Secondary Endpoints
Clinical response
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Interventions
NameTypeDescription
MK0991, caspofungin acetateDRUG -
Comparator: amphotericin BDRUG -
Comparator: lipid formulation of amphotericin B and/or azoleDRUG -
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Eligibility Criteria
Age Range16 Years — N/A
SexALL
Healthy VolunteersNo

* Patients must meet a specific definition of probable or definite invasive aspergillosis and be considered to have failed or be intolerant of standard antifungal therapy. * The patient must be at least 16 years old and if a woman of childbearing potential, must have a negative serum or urine pregna...

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