Recent Updates
Recently added Catalysts

MK0457

Phase 1

Chronic Myelogenous Leukemia in Blast Crisis | Small molecule | Oncology |Merck & Company, Inc.|Last Updated: Aug 25, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment28
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00111683MK0457 in Patients With Leukemia (0457-003)PHASE1 COMPLETED 28Jun 1, 2005May 1, 2008Aug 25, 2015 -
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Number of Participants Experiencing Dose-Limiting Toxicities (DLTs)
Part 1: up to 5 days, Part 2: up to 24 hours
Secondary Endpoints
Hematological response rate to MK-0457 as a 5-day CIV infusion
At the end of each cycle (up to 18 months)
Unlock Study Endpoints
Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MK-0457EXPERIMENTALParticipants receive MK-0457 as a continuous intravenous infusion (CIV) at assigned dose and duration
Interventions
NameTypeDescription
MK0457DRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: Part 1: * Patients with relapsed/refractory acute myelogenous leukemia (AML), poor risk myelodysplastic syndrome (MDS), B-cell acute lymphocytic leukemia (ALL), myeloproliferative diseases, or chronic myelogenous leukemia (CML) in blast crisis Part 2: * Acute myelogenous leuk...

Unlock Eligibility Criteria