Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT07300280 | A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039) | PHASE1 | RECRUITING | 60 | — | — | Dec 29, 2025 | Oct 14, 2026 | May 28, 2026 | 1 | United States |
Blood samples will be collected to determine the AUC0-inf of enlicitide in plasma
Blood samples will be collected to determine the AUC0-inf of rosuvastatin in plasma
Blood samples will be collected to determine the AUC0-last of enlicitide in plasma
Blood samples will be collected to determine the AUC0-last of rosuvastatin in plasma
Blood samples will be collected to determine the cmax of enlicitide in plasma
Blood samples will be collected to determine the cmax of rosuvastatin in plasma
| Arm | Type | Description |
|---|---|---|
| Enlicitide + Rosuvastatin Part 1 | EXPERIMENTAL | Participants in Part 1 will receive a single dose of enlicitide tablet coadministered with a single dose of rosuvastatin tablet |
| MK-0616A Part 1 | EXPERIMENTAL | Participants in Part 1 will receive a single dose of MK-0616A |
| Enlicitide + Rosuvastatin Part 2 | EXPERIMENTAL | Participants in Part 2 will receive a single dose of enlicitide tablet coadministered with a single dose of rosuvastatin tablet |
| MK-0616A Part 2 | EXPERIMENTAL | Participants in Part 2 will receive a single dose of MK-0616A formulation B |
| Name | Type | Description |
|---|---|---|
| MK-0616A | DRUG | Enlicitide/rosuvastatin fixed dose combination (FDC) or enlicitide/rosuvastatin FDC formulation B oral tablets |
| Enlicitide | DRUG | Oral tablet |
| Rosuvastatin | DRUG | Oral tablet |
The main inclusion criteria include but are not limited to the following: * Is medically healthy with no clinically significant medical history * Is a non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to study entry Exclusion Criteria: * Is unable t...