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Laropiprant

Phase 1

Rosacea | Small molecule | Dermatology |Merck & Company, Inc.|Last Updated: Mar 25, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment60
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01451619A Study of Laropiprant (MK-0524) in Participants With Moderate to Severe Erythematotelangiectatic Rosacea (MK-0524-155)PHASE1 COMPLETED 60Nov 1, 2011Apr 1, 2012Mar 25, 2015 -
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Study Endpoints
Primary Endpoints
Change in Clinician's Erythema Assessment (CEA) Scale Score from Baseline
Baseline and Week 4
Secondary Endpoints
Change in Patient Self Assessment (PSA) Score from Baseline
Baseline and Week 4
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
LaropiprantEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
LaropiprantDRUGOne 100-mg tablet orally once daily for 4 weeks
Placebo for LaropiprantDRUGOne tablet orally once daily for 4 weeks
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Moderate to severe erythematotelangiectatic rosacea with moderate to severe erythema of facial lesion * Generally healthy excluding rosacea * Presence of telangiectasia * Five or less facial inflammatory lesions * Able to restrict diet in order to avoid foods/drinks (including...

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