Recent Updates
Recently added Catalysts

TI- A

Phase 1

Healthy Volunteers | Small molecule | Other |MannKind Corporation|Last Updated: Oct 2, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment38
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01982604Comparison of 30 Units of TI (Technosphere® Insulin) Prepared With Insulin From Two Different SuppliersPHASE1 COMPLETED 38Nov 1, 2013Aug 1, 2014Oct 2, 20141 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
AUC (area-under-the-serum-insulin concentration time curve) 0 - 240 minutes
5, 10, 15, 20, 25, 30, 45, 60, 75, 90, 120, 150, 210, 240
Cmax (maximum serum insulin concentration)
5, 10, 15, 20, 25, 30, 45, 60, 75, 90, 120, 150, 210, 240
Secondary Endpoints
GIR (area-under-the-serum Glucose Infusion Rate)
0 to 360
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Sequence (Group) 1EXPERIMENTALSubjects randomized to Sequence 1 will receive TI in the following sequence: TI-Inhalation Powder A TI-Inhalation Powder B \*30 units (10 units + 20 units)
Sequence (Group) 2EXPERIMENTALSubjects randomized to Sequence 2 will receive TI in the following sequence: TI-Inhalation Powder B TI-Inhalation Powder A \*30 units (10 units + 20 units)
Interventions
NameTypeDescription
TI-Inhalation Powder ADRUGInhaled Insulin
TI-Inhalation Powder BDRUGInhaled Insulin
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Men and women aged 18 to 55 years, considered healthy based on screening physical examination, medical history, clinical chemistry, and urinalysis * HNVs with a screening blood pressure less than 140/90 mm Hg * Subjects who have hypertension controlled with up to 1 medica...

Countries:United States
Unlock Eligibility Criteria