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Afrezza Inhalant Product

Phase 3

Type2 Diabetes | Small molecule | Metabolic |MannKind Corporation|Last Updated: Jun 26, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment20
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03324776Initiating Mealtime Ultra-Rapid Acting Insulin (Afrezza) in Uncontrolled Type 2 Diabetes PatientsPHASE3 COMPLETED 20Oct 16, 2017Jun 10, 2020Jun 26, 20241 United States
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Study Endpoints
Primary Endpoints
Change in Percentage of HbA1c From Baseline to 3 Months
Baseline to 3 months

Change in percentage of HbA1c from baseline to 3 months in uncontrolled type 2 diabetes patients initially having HbA1c of 7.5 or higher and 11.5% or lower

Secondary Endpoints
Percentage of Patients With HbA1c Under 7% at 3 Months
3 months
Percent of Time With Blood Glucose (BG) Under 70 mg/dL on CGMS
3 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Addition of mealtime Afrezza Inhalation PowderOTHERPatients will be instructed to follow a Weekly Treat-to-Target BG Testing Regimen and make Afrezza dose changes according to an Afrezza Titration Algorithm
Interventions
NameTypeDescription
Afrezza Inhalant ProductDRUGMealtime Ultra-Rapid Acting Insulin
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Adult type 2 diabetes patients age 18 or older * HbA1c ≥ 7.5% and ≤ 11.5% after at least 6 months treatment with diabetes medication. Treatment may include oral agents, basal insulin or Glucagon-like peptide-1 (GLP-1) in any combination. * Patient and provider agree not to add...

Countries:United States
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