Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT02446249 | Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction | PHASE1 | ACTIVE NOT_RECRUITING | 17 | — | — | May 4, 2015 | Jul 1, 2026 | Sep 25, 2025 | 1 | United States |
| Arm | Type | Description |
|---|---|---|
| single arm dose escalation | EXPERIMENTAL | single arm dose escalation |
| Name | Type | Description |
|---|---|---|
| AAV2hAQP1 | BIOLOGICAL | Infusion of gene therapy |
* INCLUSION CRITERIA: 1. At least 18 years of age 2. History of external beam radiation therapy for head and neck cancer, with a mean dose equal to or greater than 15 Gy to a parotid gland. 3. Abnormal parotid gland function as judged by both absence of unstimulated parotid salivary flow and ...