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Talent Thoracic Stent Graft

Phase 2

Thoracic Aortic Aneurysms | Unknown | Cardiovascular |Medtronic plc.|Last Updated: Nov 2, 2021

Success Probability

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Market & Valuation

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Trial Design

ACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment379

FDA Designations

No designations recorded

Clinical trial landscape

Talent Thoracic Stent Graft · 1 trial · 1 indication

Phase 2 1
NCT00604799VALOR: The Talent Thoracic Stent Graft System Clinical StudyThoracic Aortic Aneurysms
COMPLETED379 Analytics
PHASE2COMPLETED
VALOR: The Talent Thoracic Stent Graft System Clinical Study
Thoracic Aortic AneurysmsUnlock trial analytics

Study Endpoints

Primary Endpoints

Primary Efficacy Endpoint: proportion of patients in the Test Group who have successful aneurysm treatment at the 12-month follow-up visit.
12 months
Primary Safety Endpoint: rate of "all cause" mortality of TAA repair with the Talent Thoracic Stent Graft against the literature control for open surgical repair within 1 year of follow-up.
12 months
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Test (Enrollment Completed)ACTIVE_COMPARATORPatients diagnosed with a TAA of degenerative etiology that are considered candidates for open surgical repair whom are low to moderate risk (0, 1, \& 2) per the modified SVS/AAVS criteria who meet inclusion/exclusion criteria. The aneurysm must be at least 20 mm distal to the left common carotid artery \& 20 mm proximal to the origin of the celiac artery.
Registry (Enrollment Completed)OTHERSurgical candidates of low to moderate risk (SVS 0, 1, 2) that meet the Registry Inclusion/Exclusion criteria.
High Risk (Enrollment Completed)OTHERPatients that meet one or more of the following: * High Risk (SVS 3) * Non-surgical candidates not associated with SVS scoring * Traumatic thoracic injuries
Talent Captivia (Recruiting)OTHERPatients diagnosed with a TAA of degenerative etiology that are considered candidates for open surgical repair who meet inclusion/exclusion criteria.

Interventions

NameTypeDescription
Talent Thoracic Stent GraftDEVICETEVAR
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Talent Captivia Inclusion Criteria 1. Patient is at least 18 years of age. 2. Patient is a surgical or non-surgical candidate 3. Patient has a: 1. Fusiform focal TAA AND / OR 2. Focal saccular TAA or penetrating atherosclerotic ulcer. 4. Subject's anatomy must meet all of the following anato...

Countries:United States
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Frequently asked questions about Talent Thoracic Stent Graft

What is Talent Thoracic Stent Graft used for?

Talent Thoracic Stent Graft is used for the treatment of thoracic aortic aneurysms. It is an investigational device being studied in patients with this condition. The device is currently in Phase 2 clinical development and has not been approved by regulatory authorities.

Who makes Talent Thoracic Stent Graft?

Talent Thoracic Stent Graft is being developed by Medtronic plc, a medical technology company. Medtronic's stock is traded under the ticker symbol MDT on the New York Stock Exchange.

What phase is Talent Thoracic Stent Graft in?

Talent Thoracic Stent Graft is in Phase 2 clinical development. It is an investigational device and has not received regulatory approval. The device is being studied for the treatment of thoracic aortic aneurysms.

What clinical trials is Talent Thoracic Stent Graft in?

Talent Thoracic Stent Graft has one completed clinical trial, the VALOR study (NCT00604799), which enrolled 379 participants with thoracic aortic aneurysms in the United States. The trial was active-controlled and included patients aged 18 years and older.

Is Talent Thoracic Stent Graft FDA approved?

Talent Thoracic Stent Graft is not FDA approved. It is an investigational device currently in Phase 2 clinical development for the treatment of thoracic aortic aneurysms. The device has completed one clinical trial but has not yet received marketing authorization.