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Talent Thoracic Stent Graft

Phase 2

Thoracic Aortic Aneurysms | Unknown | Cardiovascular |Medtronic plc.|Last Updated: Nov 2, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
ACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment379
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00604799VALOR: The Talent Thoracic Stent Graft System Clinical StudyPHASE2 COMPLETED 379Jul 1, 2003Jun 1, 2011Nov 2, 20211 United States
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Study Endpoints
Primary Endpoints
Primary Efficacy Endpoint: proportion of patients in the Test Group who have successful aneurysm treatment at the 12-month follow-up visit.
12 months
Primary Safety Endpoint: rate of "all cause" mortality of TAA repair with the Talent Thoracic Stent Graft against the literature control for open surgical repair within 1 year of follow-up.
12 months
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Test (Enrollment Completed)ACTIVE_COMPARATORPatients diagnosed with a TAA of degenerative etiology that are considered candidates for open surgical repair whom are low to moderate risk (0, 1, \& 2) per the modified SVS/AAVS criteria who meet inclusion/exclusion criteria. The aneurysm must be at least 20 mm distal to the left common carotid artery \& 20 mm proximal to the origin of the celiac artery.
Registry (Enrollment Completed)OTHERSurgical candidates of low to moderate risk (SVS 0, 1, 2) that meet the Registry Inclusion/Exclusion criteria.
High Risk (Enrollment Completed)OTHERPatients that meet one or more of the following: * High Risk (SVS 3) * Non-surgical candidates not associated with SVS scoring * Traumatic thoracic injuries
Talent Captivia (Recruiting)OTHERPatients diagnosed with a TAA of degenerative etiology that are considered candidates for open surgical repair who meet inclusion/exclusion criteria.
Interventions
NameTypeDescription
Talent Thoracic Stent GraftDEVICETEVAR
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Talent Captivia Inclusion Criteria 1. Patient is at least 18 years of age. 2. Patient is a surgical or non-surgical candidate 3. Patient has a: 1. Fusiform focal TAA AND / OR 2. Focal saccular TAA or penetrating atherosclerotic ulcer. 4. Subject's anatomy must meet all of the following anato...

Countries:United States
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