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Optimized echo-guided CRT pacing, normal RV pacing · 1 trial · 2 indications
| Arm | Type | Description |
|---|---|---|
| 1 | ACTIVE_COMPARATOR | Normal RV pacing |
| 2 | EXPERIMENTAL | Echo-guided optimization of pacing |
| Name | Type | Description |
|---|---|---|
| Optimized echo-guided CRT pacing | OTHER | Echo-TDI guided VV-delay optimization |
| normal RV pacing | OTHER | PM or ICD implant according to patient indication |
Inclusion Criteria: * Patients with permanent AF in whom a clinical decision had been made to undertake complete AV junction ablation and ventricular pacing because of drug-refractory, severely symptomatic, uncontrolled high ventricular rate * Patients with permanent AF, drug-refractory heart failu...
Optimized echo-guided CRT pacing, normal RV pacing is a cardiac resynchronization therapy (CRT) pacing strategy being studied for use in congestive heart failure, specifically in patients with permanent atrial fibrillation. It involves optimizing CRT delivery through echocardiographic guidance compared to normal right ventricular pacing.
Optimized echo-guided CRT pacing, normal RV pacing is developed by Medtronic plc, a medical device company traded on the New York Stock Exchange under the ticker symbol MDT. The company is conducting clinical research to evaluate this pacing approach in heart failure patients.
Optimized echo-guided CRT pacing, normal RV pacing is in Phase 3 clinical development. It is an investigational pacing strategy, not yet approved, and is being evaluated in a completed Phase 3 trial for congestive heart failure with permanent atrial fibrillation.
Optimized echo-guided CRT pacing, normal RV pacing was studied in the APAF trial, registered as NCT00111527. This Phase 3, randomized, double-blind, active-controlled trial enrolled 458 patients with congestive heart failure and permanent atrial fibrillation in Italy. The trial has been completed.
Optimized echo-guided CRT pacing, normal RV pacing is a specific cardiac resynchronization therapy (CRT) approach. It compares echocardiographically optimized CRT pacing against normal right ventricular pacing to determine the best pacing strategy for heart failure patients with atrial fibrillation.