Maze Therapeutics, Inc.

Aug 13, 2026

Maze Therapeutics Announces Appointments to Its Board of Directors

Maze Therapeutics has appointed Paula Johnson, M.D., and Sophie Kornowski, Pharm.D., to its Board of Directors. These appointments aim to enhance the company's clinical and business expertise as it advances its pipeline, including key milestones for drug candidates MZE829 and MZE782 expected in the coming years. The company focuses on developing precision medicines for kidney and metabolic diseases.

Aug 11, 2026

Maze Therapeutics Reports Second Quarter 2026 Financial Results and Recent Highlights

Maze Therapeutics has reported its financial results for Q2 2026, highlighting progress in several clinical trials. The Phase 2 HORIZON trial for MZE829 is on schedule, with data expected in late 2026 or early 2027. Additionally, the Phase 2 CIPheR trial for MZE782 in PKU has been initiated, and topline data is anticipated in 2027. The company also noted a strong balance sheet.

Jun 6, 2026

APRIL 2026 | MAZE THERAPEUTICS

Maze Therapeutics is focusing on expanding the understanding of SLC6A19 substrates. Their research indicates that SLC inhibition could play a crucial role in protecting the kidneys from the accumulation of nephrotoxic metabolites. This advancement could have significant implications for kidney health.

Jun 6, 2026

MARCH 2026 | MAZE THERAPEUTICS and Certara, Inc.

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May 27, 2026

Maze Therapeutics to Participate in Two Upcoming Investor Conferences

Maze Therapeutics, a clinical-stage biopharmaceutical company, announced its participation in two upcoming investor conferences. CEO Jason Coloma will present at the Jefferies Global Healthcare Conference on June 3, 2026, and at the Goldman Sachs Global Healthcare Conference on June 10, 2026. The company is known for developing precision medicines for kidney and metabolic diseases.

May 13, 2026

Maze Therapeutics Reports First Quarter 2026 Financial Results and Recent Highlights

Maze Therapeutics reported positive topline data from its Phase 2 HORIZON trial of MZE829, supporting its advancement into pivotal trials. The company is also on track to initiate Phase 2 trials for MZE782 targeting PKU and CKD. With a strong cash position of $528 million, Maze aims to continue its clinical execution through 2029.

Apr 22, 2026

Maze Therapeutics Announces $150 Million Registered Offering

Maze Therapeutics announced a $150 million registered offering of its common stock at $23.50 per share. The offering includes pre-funded warrants and is expected to close on April 23, 2026. The funds will primarily be used for the development of MZE829 and MZE782, targeting kidney and metabolic diseases. The offering has attracted both new and existing investors.

Mar 26, 2026

MAZE Shareholders Are Encouraged to Reach Out to Johnson Fistel for More Information About Potentially Recovering Their Losses

Johnson Fistel, PLLP is investigating potential claims on behalf of investors in Maze Therapeutics, Inc. due to losses reported after a significant stock price decline. Following the announcement of topline results from its Phase 2 HORIZON trial for MZE829, which showed a mean reduction in uACR, Maze's stock dropped about 33%. The investigation will determine if Maze's executive officers complied with federal securities laws regarding this disclosure. Investors who have suffered losses are encouraged to reach out for more information on potentially recovering their investments.

Mar 25, 2026

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Maze Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Recent Highlights

Maze Therapeutics reported strong financial results for Q4 and full year 2025, highlighting positive topline data from the Phase 2 HORIZON trial of MZE829 for APOL1-mediated kidney disease. The company plans to advance MZE829 into a pivotal program and initiate two Phase 2 trials for MZE782 in PKU and CKD in 2026. Additionally, Neil Kumar has joined the Board of Directors, enhancing the company's leadership.

Mar 25, 2026

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Maze Therapeutics Announces Positive Topline Data from Phase 2 HORIZON Trial of MZE829 Demonstrating the First Clinical Proof-of-Concept in Patients with Broad APOL1-Mediated Kidney Disease

Maze Therapeutics announced positive topline data from the Phase 2 HORIZON trial of MZE829, showing a significant mean reduction in proteinuria in patients with broad APOL1-mediated kidney disease. At week 12, MZE829 led to a 35.6% reduction in uACR, with half of the patients achieving greater than 30% reduction. The treatment was well-tolerated, and the company plans to advance MZE829 into a pivotal program.

Feb 25, 2026

Maze Therapeutics to Participate in the TD Cowen 46th Annual Health Care Conference

Maze Therapeutics, a clinical-stage biopharmaceutical company, will present at the TD Cowen 46th Annual Health Care Conference on March 4, 2026. CEO Jason Coloma, Ph.D., will lead the presentation, which will also be available via live webcast. The company focuses on developing precision medicines for kidney and metabolic diseases.

Feb 4, 2026

Maze Therapeutics to Participate in the Guggenheim Emerging Outlook: Biotech Summit 2026

Maze Therapeutics will present at the Guggenheim Emerging Outlook: Biotech Summit 2026, showcasing its advancements in precision medicines for kidney and metabolic diseases. CEO Jason Coloma will speak on February 11, 2026. The company is known for its innovative approach using human genetics to develop treatments, with key products in Phase 2 development.

Jan 5, 2026

Maze Therapeutics to Participate in the 44th Annual J.P. Morgan Healthcare Conference

Maze Therapeutics will present at the 44th Annual J.P. Morgan Healthcare Conference on January 12, 2026. CEO Jason Coloma, Ph.D., will discuss the company's advancements in small molecule precision medicines for kidney and metabolic diseases. The event will be available via live webcast and archived for 30 days.

NOVEMBER 2025 I MAZE THERAPEUTICS

The article discusses the Phase 1 study of MZE782, a specific inhibitor of SLC6A19, aimed at treating chronic kidney disease (CKD). The study evaluates the safety, tolerability, pharmacokinetics, and pharmacodynamic proof-of-mechanism in healthy adults. The findings suggest a positive outlook for MZE782 as a potential therapeutic option for CKD.

Nov 6, 2025

Maze Therapeutics Reports Third Quarter 2025 Financial Results and Recent Highlights

Maze Therapeutics reported strong financial results for Q3 2025, highlighting positive first-in-human data from its Phase 1 trial of MZE782. The company plans to initiate two Phase 2 trials in 2026 for MZE782 targeting phenylketonuria and chronic kidney disease. Additionally, the ongoing Phase 2 HORIZON trial of MZE829 is expected to provide topline data by the end of Q1 2026.

Nov 6, 2025

Maze Therapeutics to Present Additional Data Highlighting the Advancement of MZE829 and MZE782 Programs at ASN Kidney Week

Maze Therapeutics announced seven presentations at ASN Kidney Week, showcasing advancements in their MZE782 and MZE829 programs. MZE782, a novel SLC6A19 inhibitor, is in Phase 1 trials for PKU and CKD, while MZE829 is in Phase 2 for APOL1-mediated kidney disease. The company emphasizes the importance of genetic insights in developing effective therapies.

Nov 4, 2025

Maze Therapeutics to Participate in Four Upcoming Investor Conferences

Maze Therapeutics, a clinical-stage biopharmaceutical company, announced its participation in four upcoming investor conferences. The company is known for developing small molecule precision medicines targeting kidney and metabolic diseases. Its leading candidates include MZE829 for kidney disease and MZE782 for phenylketonuria and chronic kidney disease. Live webcasts of these events will be available on their website.

Oct 14, 2025

OCTOBER 2025 I MAZE THERAPEUTICS

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Oct 6, 2025

Maze Therapeutics Appoints Industry Veteran Hervé Hoppenot as Chairman of the Board of Directors

Maze Therapeutics has appointed Hervé Hoppenot as the new Chairman of the Board, succeeding Charles Homcy, M.D. Hoppenot, who has extensive experience in the biopharmaceutical industry, expressed his commitment to advancing the company's clinical programs, particularly MZE782 and MZE829. The company is well-positioned for growth with recent funding and promising clinical data.

Maze Therapeutics Announces Oversubscribed $150.0 Million Private Placement

Maze Therapeutics has announced a successful oversubscribed private placement, raising approximately $150 million. The funds will be used to further develop its lead candidates, MZE829 and MZE782, targeting kidney and metabolic diseases. The placement involves participation from both new and existing investors and is set to close on September 12, 2025.

Sep 11, 2025

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Maze Therapeutics Announces Positive First-in-Human Results from Phase 1 Trial of MZE782, Establishing Proof of Mechanism for a Potent, Oral SLC6A19 Inhibitor with Potential to Treat Phenylketonuria (PKU) and Chronic Kidney Disease (CKD)

Maze Therapeutics announced positive Phase 1 trial results for MZE782, an oral SLC6A19 inhibitor. The trial demonstrated significant increases in urinary phenylalanine excretion and a favorable safety profile, supporting its advancement to Phase 2 trials for treating phenylketonuria (PKU) and chronic kidney disease (CKD) expected to start in 2026.

Maze Therapeutics Appoints Misbah Tahir as Chief Financial Officer

Maze Therapeutics has appointed Misbah Tahir as Chief Financial Officer, effective immediately. His extensive experience in the biopharmaceutical sector is expected to support Maze's growth strategy, particularly as the company approaches significant clinical milestones. The company is focused on developing precision medicines for kidney and metabolic diseases, with promising data expected soon.

Aug 12, 2025

Maze Therapeutics Reports Second Quarter 2025 Financial Results and Recent Highlights MZE782 Phase 1 Trial in Healthy Volunteers to Provide Proof of Mechanism Data for Phenylketonuria (PKU) and Chronic Kidney Disease (CK

Maze Therapeutics has reported its second-quarter financial results for 2025, showcasing progress in its clinical trials. The company is expecting to release important proof of mechanism data for its MZE782 compound by Q3 2025, which targets conditions such as phenylketonuria and chronic kidney disease. Additionally, the Phase 2 HORIZON trial of MZE829 is actively enrolling patients, with initial results anticipated by early 2026. Despite its strong cash position, Maze reported no license revenue this quarter and incurred a net loss of $33.7 million.

May 29, 2025

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Maze Therapeutics to Participate in the Jefferies 2025 Global Healthcare Conference

Maze Therapeutics will present an overview at the Jefferies 2025 Global Healthcare Conference on June 5, 2025. CEO Jason Coloma, Ph.D., will lead the presentation, which will be available via a live webcast. The company focuses on developing precision medicines for renal, metabolic, and cardiovascular diseases.

Maze Therapeutics Reports First Quarter 2025 Financial Results and Reiterates Upcoming Milestones MZE829 Phase 2 HORIZON Trial Enrolling Patients with APOL1 Kidney Disease; Initial Data Expected in Q1 2026 MZE782 Phase 1

Maze Therapeutics reported its financial results for the first quarter of 2025, indicating a solid cash position of $294.4 million to fund ongoing clinical trials. The company emphasized progress in its MZE829 Phase 2 trial for APOL1 Kidney Disease, with initial data expected in Q1 2026, while MZE782 is currently in Phase 1 trials with results anticipated in Q3 2025. The net loss for this quarter was $32.8 million, reflecting an increase in R&D spending as therapies advance. Despite the losses, the company expresses optimism about its pipeline and the potential market impact.

May 13, 2025

Maze Therapeutics to Participate in the 3rd Annual H.C. Wainwright BioConnect Investor Conference

Maze Therapeutics, a clinical-stage biopharmaceutical company, will participate in the 3rd Annual H.C. Wainwright BioConnect Investor Conference on May 20, 2025. CEO Jason Coloma, Ph.D., will present an overview of the company and engage in one-on-one meetings. The presentation will be accessible on the company's website, with an archived replay available for 60 days. This participation reflects Maze's commitment to transparency and investor relations as they advance their precision medicine initiatives.

Mar 31, 2025

Maze Therapeutics Reports Fourth Quarter and Full-Year 2024 Financial Results and Recent Highlights MZE829 Phase 2 HORIZON Trial Enrolling Patients with APOL1 Kidney Disease (AKD); Initial Data Expected in Q1 2026 MZE782

Maze Therapeutics reported its fourth quarter and full-year financial results for 2024, revealing a net income of $52.2 million thanks to license revenue from a partnership with Shionogi. The company is advancing its MZE829 and MZE782 candidates through multiple clinical trials, with significant milestones expected in the coming years, including initial data from the MZE829 Phase 2 trial in early 2026. The company also strengthened its financial position through a $140 million IPO, providing a cash runway into the second half of 2027. Continued financial losses highlight challenges ahead as Maze pushes forward with its developmental pipeline.

Feb 7, 2025

Maze Therapeutics Doses First Patient in Phase 2 HORIZON Clinical Trial Evaluating MZE829 as a Potential Treatment for APOL1 Kidney Disease

Maze Therapeutics has begun dosing patients in its Phase 2 HORIZON clinical trial for MZE829, an oral APOL1 inhibitor aimed at treating APOL1 kidney disease (AKD). The trial includes a diverse group of patients, reflecting various severity levels of the disease, with a primary endpoint focusing on reducing proteinuria. The company's approach seeks to establish proof of concept for MZE829, which may serve as a significant advancement in managing AKD, affecting over one million patients in the U.S. There is anticipation for interim data readout by early 2026.

Jan 31, 2025

Maze Therapeutics Announces Pricing of Upsized Initial Public Offering

Maze Therapeutics has announced the pricing of its upsized initial public offering, offering 8,750,000 shares at $16.00 each, projected to yield gross proceeds of $140 million. The company plans to begin trading on the Nasdaq under the ticker 'MAZE' on January 31, 2025. The offering includes a 30-day option for underwriters to purchase additional shares. The close of the offering is expected on February 3, 2025, pending customary closing conditions. Maze focuses on developing precision medicines for renal, cardiovascular, and metabolic diseases.

Jan 8, 2025

JANUARY 2025 I MAZE THERAPEUTICS

The article discusses the privacy overview and cookie usage on the MAZE Therapeutics website. It highlights the importance of essential cookies for website functionality and user experience. Additionally, it mentions the use of Google Analytics for collecting anonymous visitor data. No specific news or updates about MAZE Therapeutics are provided.

Dec 3, 2024

After deal about-face and a spinout, Maze assembles $115M Series D

Maze Therapeutics has successfully raised $115 million in a Series D funding round following a strategic deal reversal and a spinout. This funding aims to support the company's ongoing research and development efforts. The financial backing reflects investor confidence in Maze's potential despite recent organizational changes.

Dec 3, 2024

Maze Therapeutics Announces Oversubscribed $115 Million Financing to Support Advancement of Clinical-Stage Programs and Future Pipeline

Maze Therapeutics has completed a $115 million Series D financing, co-led by Frazier Life Sciences and Deep Track Capital. This funding will support the advancement of its lead programs, MZE829 and MZE782, targeting chronic renal diseases. The company aims to optimize its Phase 2 trial for MZE829 and expects data from its Phase 1 trial of MZE782 in late 2025.

Nov 29, 2024

NOVEMBER 2024 I MAZE THERAPEUTICS

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Oct 29, 2024

OCTOBER 2024 I MAZE THERAPEUTICS

The article discusses the use of cookies on the Maze Therapeutics website, emphasizing their role in enhancing user experience and website functionality. It mentions the use of Google Analytics for collecting anonymous visitor data. However, there are no specific news events or updates related to Maze Therapeutics.

Oct 25, 2024

Maze Therapeutics Reports Positive First-in-Human Data from Phase 1 Healthy Volunteer Clinical Trial Evaluating MZE829 as a Potential Treatment for APOL1 Kidney Disease

Maze Therapeutics announced positive results from the Phase 1 trial of MZE829, an oral inhibitor targeting APOL1 for treating APOL1-mediated kidney disease. The trial showed that MZE829 was well tolerated and supported once daily dosing. The company plans to advance to a Phase 2 trial in early 2025, aiming to include a diverse patient population.

Oct 15, 2024

Maze Therapeutics to Present New Data Supporting Advancement of MZE829 and MZE782 Clinical Development at American Society of Nephrology’s Kidney Week and American Society of Human Genetics Annual Meeting

Maze Therapeutics announced the presentation of new data for its clinical programs MZE829 and MZE782 at upcoming conferences. The Phase 1 trial data for MZE829 supports its advancement to Phase 2, expected to start in early 2025. Additionally, preclinical data for MZE782 supports its recent initiation of Phase 1 trials in healthy volunteers.

Oct 1, 2024

Maze Therapeutics Initiates Phase 1 First-in-Human Trial Evaluating MZE782 as a Potential Treatment for Chronic Kidney Disease

Maze Therapeutics has initiated a Phase 1 clinical trial for MZE782, a potential first-in-class treatment for chronic kidney disease (CKD). The trial, involving healthy volunteers, aims to evaluate the safety and efficacy of MZE782, which targets the SLC6A19 transporter. Initial results are expected in the second half of 2025, potentially benefiting millions of CKD patients with inadequate responses to current therapies.

Sep 4, 2024

SEPTEMBER 2024 I MAZE THERAPEUTICS

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Jul 15, 2024

Maze Corporate Presentation – July 2024

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May 10, 2024

After FTC stalled Sanofi deal, Shionogi secures Maze’s Pompe disease drug for $150M

Shionogi has acquired Maze's Pompe disease drug for $150 million following a stalled deal with Sanofi due to FTC intervention. This acquisition is seen as a strategic move to bolster Shionogi's offerings in the biopharma sector. The deal highlights the ongoing interest in treatments for Pompe disease.

May 10, 2024

MAZEFDA Updates

Shionogi & Co., Ltd. and Maze Therapeutics, Inc. Announce Exclusive Worldwide License Agreement for MZE001, a Novel Therapeutic Candidate for the Treatment of Pompe Disease

Shionogi & Co., Ltd. has entered into an exclusive worldwide license agreement with Maze Therapeutics for MZE001, a novel oral therapy aimed at treating Pompe disease. This agreement, which includes a $150 million upfront payment and potential milestone payments, positions Shionogi to expand its pipeline in rare diseases. MZE001 is expected to address unmet medical needs by reducing glycogen accumulation in patients.

Feb 26, 2024

Maze Therapeutics to Participate in Upcoming Investor Conferences

Maze Therapeutics announced its participation in several upcoming investor conferences in February and March 2024. The events include presentations and one-on-one meetings at the Evercore ISI 2024 Emerging Biotech Conference, Cowen Healthcare Conference, and Leerink Partners Global Biopharma Conference. This engagement highlights the company's commitment to transparency and investor relations.

Jan 10, 2024

2024 J.P. Morgan Healthcare Conference Presentation

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Dec 14, 2023

Maze Therapeutics Announces Initiation of Dosing in Phase 1 Trial Evaluating MZE829, a Novel Oral APOL1 Inhibitor, as a Potential Treatment for APOL1 Kidney Disease

Maze Therapeutics has commenced dosing in a Phase 1 trial for MZE829, an oral APOL1 inhibitor aimed at treating APOL1-mediated kidney disease. This trial represents the second program from their Compass platform to enter clinical development. The trial will assess safety and pharmacokinetics in healthy volunteers, with results expected in late 2024.

Dec 11, 2023

MAZEFDA Updates

Maze Therapeutics Announces FTC Action Seeking to Block Collaboration and License Agreement with Sanofi Regarding MZE001, a Potential Oral Substrate Reduction Therapy for Pompe Disease

Maze Therapeutics announced that the FTC is seeking to block its collaboration with Sanofi regarding the license agreement for MZE001, a treatment for Pompe disease. This complaint marks a significant regulatory challenge, as it is reportedly the first time the FTC has attempted to block a license for a Phase 1 investigational medicine. Maze's CEO expressed disappointment and plans to review the complaint while continuing to advance other programs.

Nov 13, 2023

NOVEMBER 2023 | MAZE THERAPEUTICS

The article provides an overview of the cookie policy for the Maze Therapeutics website. It details the use of essential cookies for website functionality and analytics. The content emphasizes user experience and the importance of cookies in recognizing returning visitors and measuring website performance.

Nov 6, 2023

Maze Therapeutics Highlights New Preclinical Data Supporting Advancement of APOL1 Inhibitor Candidate Toward Clinical Evaluation for APOL1 Kidney Disease

Maze Therapeutics presented promising preclinical data on its APOL1 inhibitor, MZE829, at the ASN Kidney Week 2023. The data indicate a significant reversal of albuminuria in a chronic mouse model of APOL1-mediated kidney disease. The company plans to initiate a Phase 1 trial by the end of 2023, marking a significant step toward clinical evaluation.

Oct 26, 2023

Maze Therapeutics to Present New Data for APOL1 Kidney Disease in Proprietary Chronic Preclinical Model Demonstrating Reversal of Albuminuria

Maze Therapeutics will present new findings on APOL1 kidney disease at Kidney Week 2023. The research showcases the reversal of albuminuria in a chronic mouse model through small molecule inhibition of APOL1. This presentation reflects the company's commitment to developing innovative treatments for genetic diseases.

Oct 13, 2023

OCTOBER 2023 | MAZE THERAPEUTICS Million Veteran Program and Vanderbilt University Medical Center

The article provides a privacy overview regarding the use of cookies on the MAZE Therapeutics website. It highlights the necessity of essential cookies for website functionality and measurement purposes. Additionally, it mentions the use of Google Analytics for collecting anonymous visitor data to improve the website experience.

Oct 12, 2023

Maze Therapeutics Announces Publication of Research Demonstrating Newly Identified Variant for APOL1 Kidney Disease is Associated with Reduced Risk of APOL1 Kidney Disease

Maze Therapeutics has published research in JASN demonstrating that the APOL1 variant p.N264K is associated with a reduced risk of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) among carriers of high-risk variants. This discovery enhances the understanding of APOL1's role in kidney injury and supports the development of a small molecule inhibitor aimed at treating APOL1-mediated kidney disease, with a Phase 1 trial expected to start by the end of 2023.

Sep 26, 2023