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BAY94-9392

Phase 1

Diagnostic Imaging | Small molecule | Oncology |Lantheus Holdings, Inc.|Last Updated: Nov 13, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDBiomarker
Total Trials1
Total Enrollment46
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01103310Radiation Dosimetry, Metabolism, Pharmacokinetics, Safety and Tolerability and PET Imaging With BAY94-9392 in Healthy Volunteers and Patients With Cancer or InflammationPHASE1 COMPLETED 46Apr 1, 2010Aug 1, 2011Nov 13, 20143 United States, Germany +1
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Study Endpoints
Primary Endpoints
Visual assessment of lesion
Day of study drug administration
Secondary Endpoints
Quantitative analysis of BAY94-9392 uptake into lesions (Standardized Uptake Values = SUVs)
Day of study drug administration
Electrocardiogram (ECG)
At least twice within 2 days after treatment
Blood pressure
At least twice within 2 days after treatment
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeDIAGNOSTIC
Treatment Arms
ArmTypeDescription
Arm 1EXPERIMENTALCancer patients, single intravenous bolus injection of 300 MBq BAY94-9392 on day one of the treatment period, PET/CT
Arm 2EXPERIMENTALHealthy volunteers, single intravenous bolus injection of 300 MBq BAY94-9392 on day one of the treatment period, whole body PET/CT for determination of effective dose, kinetics of BAY94-9392 in blood
Interventions
NameTypeDescription
BAY94-9392DRUG -
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Eligibility Criteria
Age Range35 Years — 75 Years
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion criteria: In Germany Healthy volunteers * Males/females ≥ 50 and ≤ 65 years Patients * Males/females ≥ 35 and ≤ 75 years * histologically confirmed diagnosis of non small cell lung cancer or adenocarcinoma of the breast with a positive FDG-PET or * patient with primary prostate cancer sc...

Countries:United StatesGermanySouth Korea
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Competitive Landscape -Diagnostic and Imaging 9 trials