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BAY1075553

Phase 1

Diagnostic Imaging | Small molecule | Other |Lantheus Holdings, Inc.|Last Updated: Jan 21, 2013

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials1
Total Enrollment14

FDA Designations

No designations recorded

Clinical trial landscape

BAY1075553 · 1 trial · 1 indication

Phase 1 1
NCT01287845PET/CT (Positron Emission Tomography/Computed Tomography) Imaging for Safety and Tolerability and Diagnostic Performance of BAY1075553 in Patients With Prostate Cancer and Healthy VolunteersDiagnostic Imaging
COMPLETED14 Analytics
PHASE1COMPLETED
PET/CT (Positron Emission Tomography/Computed Tomography) Imaging for Safety and Tolerability and Diagnostic Performance of BAY1075553 in Patients With Prostate Cancer and Healthy Volunteers
Diagnostic ImagingUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety parameters, for example laboratory and electrocardiogram abnormalities
Day 2
Effective radiation dose given in mSv (milliSievert) in healthy volunteers
Day 1

Secondary Endpoints

Overall lesion detection rate
Day 1
Lesion detection rate in comparison to histology, where available (cancer lesion detection rate)
Day 1
Lesion detection rate in comparison to MRI (Magnetic Resonance Imaging) and/or [11C] (11Carbon)- or [18F] (18Fluor)-choline PET/CT (whenever available)
Day 1
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeDIAGNOSTIC

Treatment Arms

ArmTypeDescription
Arm 1EXPERIMENTAL -
Arm 2EXPERIMENTAL -

Interventions

NameTypeDescription
BAY1075553DRUGCancer patients, single intravenous bolus injection of 300 MBq BAY1075553 over 60 seconds on the treatment day 1
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Eligibility Criteria

Age Range18 Years to N/A
SexMALE
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Part 1: Healthy volunteers only \-- Males ≥ 40 years of age * Part 2: Prostate cancer patients * Males ≥ 18 years of age * Serum PSA (Prostate-Specific Antigen) value above normal. * Patients had an MRI and/or a positive \[11C\] - or \[18F\] -choline PET/CT for prima...

Countries:United StatesAustria
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Competitive Landscape -Diagnostic and Imaging 9 trials (matched to "Diagnostic Imaging")

Frequently asked questions about BAY1075553

What is BAY1075553 used for?

BAY1075553 is an investigational small molecule being studied for diagnostic imaging. It was evaluated in a Phase 1 clinical trial for its safety, tolerability, and diagnostic performance in patients with prostate cancer and healthy volunteers using PET/CT imaging.

Who makes BAY1075553?

BAY1075553 is being developed by Lantheus Holdings, Inc., a company traded on the NASDAQ under the ticker LNTH. The company is conducting clinical research on this investigational diagnostic imaging agent.

What phase is BAY1075553 in?

BAY1075553 is in Phase 1 clinical development. It is an investigational agent and has not been approved by regulatory authorities. The Phase 1 trial has been completed, and the drug remains in early-stage clinical research.

What clinical trials is BAY1075553 in?

BAY1075553 has one completed Phase 1 clinical trial registered as NCT01287845. The study evaluated PET/CT imaging for safety, tolerability, and diagnostic performance of BAY1075553 in patients with prostate cancer and healthy volunteers. The trial enrolled 14 male participants aged 18 years and older.

Is BAY1075553 the same as another drug?

BAY1075553 is the primary name used in clinical research for this investigational diagnostic imaging agent. No alternative names have been reported in the available clinical trial information.