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Equilia Vagal Nerve Stimulation

Phase 2

Heart Failure With Reduced Ejection Fraction | Unknown | Cardiovascular |LivaNova PLC|Last Updated: Mar 13, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment15
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02113033VAgal Nerve Stimulation: safeGUARDing Heart Failure PatientsPHASE2 COMPLETED 15Oct 7, 2014Sep 20, 2016Mar 13, 20186 Belgium, France +2
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Study Endpoints
Primary Endpoints
The primary outcome measure is the freedom from Serious Adverse Device Effects, defined as the number of patients without SADEs.
6 Months

Adverse device effects will be sub-classified into device-related or procedure-related, when the adverse event has a generic cause independent from the device itself and occurs within 30 days of the implant procedure.

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Treated with Equilia systemEXPERIMENTALImplantation and activation of the Vagus Nerve Stimulator, nerve electrode and cardiac lead
Interventions
NameTypeDescription
Equilia® Vagal Nerve StimulationDEVICEVagal Nerve Stimulation synchronized with cardiac activity
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: 1. Left ventricular dysfunction of ischemic or idiopathic dilated cardiomyopathy etiology, characterized by LVEF \< 40% 2. Chronic heart failure with symptoms characterized by NYHA functional class II or III at the time of enrollment despite optimal drug regimen 3. Optimal drug ...

Countries:BelgiumFranceNorwaySerbia
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