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OPC1

Phase 1

Spinal Cord Injury Cervical | Monoclonal antibody | Neurology |Lineage Cell Therapeutics, Inc.|Last Updated: Feb 12, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment10

FDA Designations

No designations recorded

Clinical trial landscape

OPC1 · 1 trial · 5 indications

Phase 1 1
NCT06841770A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord InjurySpinal Cord Injury Cervical
RECRUITING10 Analytics
PHASE1RECRUITING
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
Spinal Cord Injury CervicalUnlock trial analytics

Study Endpoints

Primary Endpoints

Frequency and Severity of Adverse Events Related to the Delivery Device or Injection Procedure Through 30 Days
One month after LCTOPC1 injection

Frequency and severity of the MI PSD System or injection procedure related adverse events (AEs) through 30 days (1 month).

Secondary Endpoints

Frequency and Severity of Adverse Events Related to LCTOPC1 and/or the Concomitant Immunosuppression Through 90 Days
Three months after LCTOPC1 injection
Incidence of MRI Findings Indicative of Deterioration or Safety-Related Changes at 90 Days
Three months after LCTOPC1 injection
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
LCTOPC1EXPERIMENTALOpen Label Single Injection of LCTOPC1 at a Single Time Point

Interventions

NameTypeDescription
OPC1BIOLOGICALOne injection of 10 million LCTOPC1 cells will be delivered to the target injection site of the damaged spinal tissue.
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: 1. Sensorimotor complete, traumatic SCI (ASIA Impairment Scale A) or sensory incomplete, traumatic SCI (ASIA Impairment Scale B) 2. For subjects with subacute injury, International Standards for Neurological Classification of SCI (ISNCSCI) Neurological Level of Injury (NLI) from...

Countries:United States
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Frequently asked questions about OPC1

What is OPC1 used for?

OPC1 is an investigational cell therapy being developed for spinal cord injury, specifically cervical spinal cord injury. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities.

Who makes OPC1?

OPC1 is being developed by Lineage Cell Therapeutics, Inc., a biopharmaceutical company traded on the NYSE American under the ticker symbol LCTX.

What phase is OPC1 in?

OPC1 is in Phase 1 clinical development. It is an investigational product and has not received regulatory approval. A Phase 1 trial is currently recruiting participants.

What clinical trials is OPC1 in?

OPC1 is being studied in a Phase 1 clinical trial with the identifier NCT06841770. This trial is evaluating the safety of a delivery device for administering LCTOPC1 in participants with spinal cord injury, including cervical and thoracic spinal cord injury.

Is OPC1 the same as LCTOPC1?

Yes, OPC1 is also known as LCTOPC1. The clinical trial NCT06841770 refers to the product as LCTOPC1, which is the same investigational cell therapy being developed by Lineage Cell Therapeutics.