Recent Updates
Recently added Catalysts

EOS884448

Phase 1

Advanced Cancer | Small molecule | Oncology |iTeos Therapeutics, Inc.|Last Updated: Sep 19, 2024

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

EOS884448 · 1 trial · 1 indication

Phase 1 1
NCT04335253First-In-Human Study of EOS884448 in Participants with Advanced Cancers.Advanced Cancer
COMPLETED40 Analytics
PHASE1COMPLETED
First-In-Human Study of EOS884448 in Participants with Advanced Cancers.
Advanced CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of participants with Adverse Events
From first dose date to 90 days after the last dose (up to 48 weeks)
Percentage of participants who experience a Dose Limiting Toxicity
From first study treatment administration through Day 28
Define the recommended Phase 2 dose (RP2D) of EOS884448 in participants with advanced tumors.
up to 48 weeks

Secondary Endpoints

Mean and median Area under the curve (AUC) of EOS884448 at each dose level
up to 48 weeks
Mean and median Maximum concentration (Cmax) of EOS884448 at each dose level
up to 48 weeks
Percentage of participants with Objective Response as determined by Investigator according to RECIST v1.1or per other specific response criteria according to their tumor type.
From study enrollment until participant discontinuation, first occurrence of progressive disease, or death from any cause, whichever occurs first (approximately 48 weeks)
Unlock Study Endpoints

Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Multiple Ascending DoseEXPERIMENTALDose escalation according to cohort allocation

Interventions

NameTypeDescription
EOS884448DRUGMultiple Ascending Dose
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites4

Inclusion Criteria: 1. Be willing to provide a signed written informed consent for the trial and consent for biopsies before and during administration of EOS884448 2. Be more than18 years of age on day of signing informed consent. 3. Have histologically or cytologically confirmed advanced or metast...

Countries:Belgium
Unlock Eligibility Criteria

Competitive Landscape -Cancer 5 trials (matched to "Advanced Cancer")

Frequently asked questions about EOS884448

What is EOS884448 used for?

EOS884448 is an investigational small molecule being studied for the treatment of advanced cancer. It is in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being evaluated in patients with advanced cancers who are at least 18 years old.

Who is developing EOS884448?

EOS884448 is being developed by iTeos Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol ITOS. The company is conducting clinical research on this investigational oncology drug candidate.

What phase is EOS884448 in?

EOS884448 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or other regulatory agencies. The drug is still in the early stages of clinical testing for advanced cancer.

What clinical trials is EOS884448 in?

EOS884448 has one completed Phase 1 clinical trial, identified as NCT04335253. This first-in-human study enrolled 40 participants with advanced cancers and was conducted in Belgium. The trial was not randomized, double-blind, or controlled, and did not use biomarker selection.

Is EOS884448 the same as any other drug?

No alternative names for EOS884448 have been reported. The drug is known only by this identifier in clinical development. It is a small molecule being investigated by iTeos Therapeutics for advanced cancer.