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IW-6118

Phase 2

Healthy | Small molecule | Other |Ironwood Pharmaceuticals, Inc.|Last Updated: Aug 11, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment90
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01107236Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar ExtractionPHASE2 COMPLETED 90Jun 1, 2010Aug 1, 2010Aug 11, 20221 United States
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Study Endpoints
Primary Endpoints
Safety Assessments
Duration of the Study

Adverse events, vital signs, laboratory parameters, and ECGs will be assessed.

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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
IW-6118EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Naproxen SodiumACTIVE_COMPARATOR -
Interventions
NameTypeDescription
IW-6118DRUGSingle dose
Matching PlaceboDRUGSingle dose of matching placebo for IW-6118 and/or matching placebo for naproxen sodium
Naproxen SodiumDRUGSingle dose
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Eligibility Criteria
Age Range18 Years — 30 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Between 18 and 30 years old at time of screening; * BMI \> 18.5 and \< 30.0; * In overall good health with no clinically-significant laboratory, ECG, or physical exam findings; * Patient requires two ipsilateral third molar extractions of which one must be a full or partial bo...

Countries:United States
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