Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT04018950 | Study to Determine the Excretion and Metabolism of 14C-ETX2514 Administered Intravenously in Healthy Male Subjects | PHASE1 | COMPLETED | 8 | — | — | Jun 21, 2019 | Jul 26, 2019 | Aug 30, 2019 | 1 | United States |
| NCT03985410 | Study Evaluating the Effect of ETX2514 on Cardiac Repolarization in Healthy Male or Female Volunteers | PHASE1 | COMPLETED | 32 | — | — | May 23, 2019 | Jul 24, 2019 | Aug 30, 2019 | 1 | United States |
| Arm | Type | Description |
|---|---|---|
| ETX2514 and 14C-ETX2514 | EXPERIMENTAL | Participants will receive a single intravenous infusion of 1 gram non-labeled ETX2514 and 1 microCurie (µCi) of 14C-ETX2514 in normal saline, administered as a 3-hour infusion. |
| Treatment Sequence ABC | EXPERIMENTAL | Participants will receive a single 3-hour intravenous (IV) infusion of 4 grams (g) of ETX2514 (supratherapeutic dose) (Treatment A), followed by a single 3-hour IV infusion of placebo for ETX2514 (Treatment B), followed by a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 milligrams (mg) open-label moxifloxacin given at the end of the infusion (Treatment C). There will be 7 ± 2 days washout between treatments. |
| Treatment Sequence ACB | EXPERIMENTAL | Participants will receive a single 3-hour IV infusion of 4 g of ETX2514 (supratherapeutic dose) (Treatment A), followed by a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 mg open-label moxifloxacin given at the end of the infusion (Treatment C), followed by a single 3-hour IV infusion of placebo for ETX2514 (Treatment B). There will be 7 ± 2 days washout between treatments. |
| Treatment Sequence BAC | EXPERIMENTAL | Participants will receive a single 3-hour IV infusion of placebo for ETX2514 (Treatment B), followed by a single 3-hour IV infusion of 4 g of ETX2514 (supratherapeutic dose) (Treatment A), followed by a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 mg open-label moxifloxacin given at the end of the infusion (Treatment C). There will be 7 ± 2 days washout between treatments. |
| Treatment Sequence BCA | EXPERIMENTAL | Participants will receive a single 3-hour IV infusion of placebo for ETX2514 (Treatment B), followed by a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 mg open-label moxifloxacin given at the end of the infusion (Treatment C), followed by a single 3-hour IV infusion of 4 g of ETX2514 (supratherapeutic dose) (Treatment A). There will be 7 ± 2 days washout between treatments. |
| Treatment Sequence CAB | EXPERIMENTAL | Participants will receive a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 mg open-label moxifloxacin given at the end of the infusion (Treatment C), followed by a single 3-hour IV infusion of 4 g of ETX2514 (supratherapeutic dose) (Treatment A), followed by a single 3-hour IV infusion of placebo for ETX2514 (Treatment B). There will be 7 ± 2 days washout between treatments. |
| Treatment Sequence CBA | EXPERIMENTAL | Participants will receive a single 3-hour IV infusion of placebo for ETX2514 and a single oral dose of 400 mg open-label moxifloxacin given at the end of the infusion (Treatment C), followed by a single 3-hour IV infusion of placebo for ETX2514 (Treatment B), followed by a single 3-hour IV infusion of 4 g of ETX2514 (supratherapeutic dose) (Treatment A). There will be 7 ± 2 days washout between treatments. |
| Name | Type | Description |
|---|---|---|
| ETX2514 | DRUG | intravenous infusion |
| 14C-ETX2514 | DRUG | intravenous infusion |
| Placebo | DRUG | intravenous infusion |
| moxifloxacin | DRUG | oral tablet |
Inclusion Criteria: * Healthy male participants, between 18 and 55 years of age (inclusive) at the time of Screening * Body mass index (BMI) ≥ 18.0 kilograms per meters squared (kg/m\^2) and ≤ 32.0 kg/m\^2 at Screening and weight between 55.0 and 100.0 kg (both inclusive) at Screening and Day -1 * ...