Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT02251821 | JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis | PHASE2 | ACTIVE NOT_RECRUITING | 61 | — | — | Oct 20, 2014 | Dec 28, 2025 | Dec 4, 2025 | 1 | United States |
OS was defined as the time from date of transplantation to date of death due to any cause. In the absence of confirmation of death, survival time was censored to last date the participant was known to be alive. The 2-year survival probability was estimated using the Kaplan-Meier method and a 2-sided 95% confidence interval (CI).
| Arm | Type | Description |
|---|---|---|
| Treatment (ruxolitinib, transplant) | EXPERIMENTAL | Patients receive a ruxolitinib and undergo myeloablative or reduced-intensity conditioning followed by transplant and GVHD prophylaxis; see detailed description. |
| Name | Type | Description |
|---|---|---|
| Allogeneic Hematopoietic Stem Cell Transplantation | PROCEDURE | Undergo allogeneic hematopoietic stem cell transplant |
| Busulfan | DRUG | Given IV |
| Cyclophosphamide | DRUG | Given IV |
| Fludarabine Phosphate | DRUG | Given IV |
| Laboratory Biomarker Analysis | OTHER | Correlative studies |
| Melphalan | DRUG | Given IV |
| Methotrexate | DRUG | Given IV |
| Mycophenolate Mofetil | DRUG | Given IV or PO |
| Ruxolitinib | DRUG | Given PO |
| Tacrolimus | DRUG | Given IV or PO |
| Total-Body Irradiation | RADIATION | Undergo TBI |
| Umbilical Cord Blood Transplantation | PROCEDURE | Undergo umbilical cord blood transplant |
Inclusion Criteria: PART 1: * PART 1: Disease criteria * Diagnosis of primary MF (PMF) as defined by the 2008 World Health Organization classification system or diagnosis of secondary MF as defined by the International Working Group (IWG) for Myeloproliferative Neoplasms Research and Treatment ...