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IMA202 Product

Phase 1

Solid Tumor, Adult | Small molecule | Oncology |Immatics N.V.|Last Updated: Feb 4, 2025

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment16

FDA Designations

No designations recorded

Clinical trial landscape

IMA202 Product · 1 trial · 4 indications

Phase 1 1
NCT03441100TCR-engineered T Cells in Solid Tumors: IMA202-101Solid Tumor, Adult
COMPLETED16 Analytics
PHASE1COMPLETED
TCR-engineered T Cells in Solid Tumors: IMA202-101
Solid Tumor, AdultUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of adverse events (AE)
up to 3 years post treatment

Secondary Endpoints

Persistence of T-cells
up to 3 years post treatment
Tumor response per Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 and immune-related RECIST (irRECIST)
up to 12 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Experimental: IMA202 ProductEXPERIMENTAL* Pre-conditioning by non-myeloablative chemotherapy with Fludarabine and Cyclophosphamide * One dose of IMA202 product will be infused intravenously. Four dose levels will be evaluated. At least two patients per cohort will be treated. * Post-infusion of IMA202 product, administration of low dose recombinant human interleukin-2

Interventions

NameTypeDescription
IMA202 ProductDRUGThe cell dose will be based on viable CD3+CD8+ HLA-Dextramer+ cells per body surface area (BSA) as defined by the Mosteller formula.
IMADetect®DEVICEIMADetect® is developed as a companion diagnostic to aid in selecting patients with relapsed and/or refractory solid cancers who might be eligible for enrollment in clinical trials. IMADetect® is intended for investigational use only.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Pathologically confirmed advanced and/or metastatic solid tumor * Patients may enter screening procedure before, during, or after the last available indicated standard of care treatment. There is no limitation for prior anti cancer treatments. * Eastern Cooperative Oncology Gr...

Countries:United StatesGermany
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Frequently asked questions about IMA202 Product

What is IMA202 Product used for?

IMA202 Product is an investigational cell therapy being studied for the treatment of solid tumors in adults, including refractory and recurrent cancers. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

How does IMA202 Product work?

IMA202 Product is a TCR-engineered T cell therapy designed to recognize and attack cancer cells. It is being developed by Immatics N.V. (IMTX) as a potential treatment for solid tumors.

Who makes IMA202 Product?

IMA202 Product is being developed by Immatics N.V., a biopharmaceutical company listed on the stock exchange under the ticker IMTX.

What phase is IMA202 Product in?

IMA202 Product is in Phase 1 clinical development. It is an investigational therapy and has not been approved by the FDA or any other regulatory agency.

What clinical trials is IMA202 Product in?

IMA202 Product has one completed Phase 1 clinical trial, NCT03441100, titled 'TCR-engineered T Cells in Solid Tumors: IMA202-101'. This trial enrolled 16 adult patients with solid tumors and was conducted in the United States and Germany.

Is IMA202 Product the same as IMA202?

IMA202 Product is the name used in clinical trial records for the investigational therapy. It is also referred to as IMA202 in the context of the study 'TCR-engineered T Cells in Solid Tumors: IMA202-101'.