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Petrelintide

Phase 1

Obesity & Overweight | Small molecule | Metabolic |Icon Plc|Last Updated: Apr 8, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07338214Investigating the Pharmacokinetics of Petrelintide Using Different Drug Product ConcentrationsPHASE1 COMPLETED 48Dec 17, 2025Mar 31, 2026Apr 8, 20261 Germany
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Study Endpoints
Primary Endpoints
To investigate the Pharmacokinetics of a single dose administration of petrelintide administered subcutaneously using 4 different drug product concentrations in participants with overweight or obesity
Day 1 - day 50 (+/- 2)

Area under the petrelintide plasma concentration time curve from time zero to infinity after a single dose of petrelintide (AUC0-inf)

Secondary Endpoints
To investigate the Pharmacokinetics of a single dose administration of petrelintide administered subcutaneously using 4 different drug product concentrations in participants with overweight or obesity
Day 1 - day 50 (+/- 2)
To investigate the safety and tolerability of a single dose administration of petrelintide administered subcutaneously using 4 different drug product concentrations in participants with overweight or obesity
Day 1 - day 50 (+/- 2)
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Arm AACTIVE_COMPARATOREach participant will receive a single subcutaneous dose of petrelintide strength A on Day 1.
Arm BACTIVE_COMPARATOREach participant will receive a single subcutaneous dose of petrelintide strength B on Day 1.
Arm CACTIVE_COMPARATOREach participant will receive a single subcutaneous dose of petrelintide strength C on Day 1.
Arm DACTIVE_COMPARATOREach participant will receive a single subcutaneous dose of petrelintide strength D on Day 1.
Interventions
NameTypeDescription
PetrelintideDRUGSolution administered with a syringe
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Eligibility Criteria
Age Range18 Years — 64 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Signed and dated informed consent obtained before any study-related activities. Study-related activities are any procedures that would not have been done during normal management of the participant * BMI: ≥27.0 kg/m2, at screening and Day -1 * Have sufficient venous access to ...

Countries:Germany
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