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MT1980

Phase 1

Neuroinflammatory Response | Small molecule | Other |Icon Plc|Last Updated: Nov 2, 2022

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

No designations recorded

Clinical trial landscape

MT1980 · 1 trial · 1 indication

Phase 1 1
NCT05429840Safety & PK of Single Doses of MT1980Neuroinflammatory Response
COMPLETED24 Analytics
PHASE1COMPLETED
Safety & PK of Single Doses of MT1980
Neuroinflammatory ResponseUnlock trial analytics

Study Endpoints

Primary Endpoints

Treatment-related adverse events
Day 1 to Day 11

Descriptive statistics comparing MT1980 \& placebo following a single dose of study drug. Number of subjects, number of events and severity of events to be reported

Secondary Endpoints

Systemic bioavailability of MT1980
72 hours post dose
Level of MT1980 in CSF
up to 7 hours post dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Part 1 MT1980EXPERIMENTAL -
Part 1 PlaceboPLACEBO_COMPARATOR -
Part 2 MT1980 Dose Level 1EXPERIMENTAL -
Part 2 MT1980 Dose Level 2EXPERIMENTAL -
Part 2 PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
MT1980DRUGsingle dose
PlaceboDRUGsingle dose
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy volunteers with good physical and mental health * Body Mass Index 18 to 30 kg/m2 * Men \& women of child-bearing potential must agree to use adequate contraception * Willing \& able to provide written informed consent and to communicate and participate in the study Ex...

Countries:Netherlands
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Frequently asked questions about MT1980

What is MT1980 used for?

MT1980 is an investigational small molecule being developed for the treatment of neuroinflammatory response. It is currently in Phase 1 clinical development, meaning it has not yet been approved by regulatory authorities and its safety and efficacy are still being evaluated in human trials.

Who makes MT1980?

MT1980 is being developed by Icon Plc, a biopharmaceutical company listed on the NASDAQ under the ticker symbol ICLR. The company is conducting clinical trials to evaluate the safety and pharmacokinetics of this investigational drug.

What phase is MT1980 in?

MT1980 is in Phase 1 clinical development. A Phase 1 trial has been completed, which involved 24 participants and was designed to assess the safety and pharmacokinetics of single doses of the drug. The drug remains investigational and is not yet approved for any use.

What clinical trials is MT1980 in?

MT1980 has one completed clinical trial registered under NCT05429840, titled 'Safety & PK of Single Doses of MT1980'. This Phase 1 study enrolled 24 participants in the Netherlands, including healthy volunteers, and was a randomized, double-blind, placebo-controlled trial.

Is MT1980 the same as any other drug?

No alternative names for MT1980 have been reported. The drug is known solely by its developmental code name MT1980 and is not identified as being the same as any other marketed or investigational product.