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IX-01

Phase 2

Premature Ejaculation | Small molecule | Other |Icon Plc|Last Updated: Aug 17, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment88
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02232425IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE)PHASE2 COMPLETED 88Sep 1, 2014Oct 1, 2015Aug 17, 202010 United States, Australia
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Study Endpoints
Primary Endpoints
Mean Fold Change in Geometric Mean Intravaginal Ejaculatory Latency Time (IELT)
Last 4 weeks of treatment compared to baseline

IX-01 versus placebo. Intravaginal ejaculatory latency time (IELT) was defined as the time from the initiation of sexual intercourse (penetration) until ejaculation occurred

Secondary Endpoints
Proportion of Participants Rating Their PE as Better or Much Better, on the Clinical Global Impression of Change (CGIC) Scale
Baseline to the end of treatment (approximately 8 weeks)
Proportion of Participants With Greater Than or Equal to (≥) 2.5 Fold Increase in Intravaginal Ejaculatory Latency Time (IELT)
Last 4 weeks of treatment compared to baseline
Mean Fold Change in Arithmetic IELT (Intravaginal Ejaculatory Latency Time)
Last 4 weeks of treatment compared to baseline
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Drug: IX-01EXPERIMENTALTwo to four 200 mg capsules administered orally, 1-6 hours prior to sexual activity
PlaceboPLACEBO_COMPARATORTwo to four capsules administered orally, 1-6 hours prior to sexual activity
Interventions
NameTypeDescription
IX-01DRUG -
PlaceboDRUG -
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Eligibility Criteria
Age Range18 Years — 60 Years
SexMALE
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: * In stable (≥ 6 months) heterosexual relationship * Have life-long (primary) premature ejaculation * Have premature ejaculation confirmed by Intravaginal Ejaculatory Latency Time (IELT) less than or equal to (≤) 1 minute on ≥ 75% attempts at sexual intercourse * Meet other aspe...

Countries:United StatesAustralia
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