Recent Updates
Recently added Catalysts

Intravesical Recombinant Mycobacterium

Phase 1

NMIBC | Monoclonal antibody | Oncology |ImmunityBio, Inc.|Last Updated: Mar 27, 2026

Target and mechanism

ModalityMonoclonal antibody

Also known as Intravesical Recombinant Mycobacterium (rMBCG)

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

Intravesical Recombinant Mycobacterium · 1 trial · 1 indication

Phase 1 1
NCT06800963ResQ133A-NMIBC: Intravesical Recombinant Mycobacterium (rMBCG) in Participants With NMIBC Eligible to Receive Intravesical Tice BCGNMIBC
RECRUITING40 Analytics
PHASE1RECRUITING
ResQ133A-NMIBC: Intravesical Recombinant Mycobacterium (rMBCG) in Participants With NMIBC Eligible to Receive Intravesical Tice BCG
NMIBCUnlock trial analytics

Study Endpoints

Primary Endpoints

The primary endpoint is to assess safety as measured by the incidence and severity of adverse events.
Approximately 7 months

Safety assessments will include demographics/medical history, vital signs, hematology, chemistry, urinalysis, and pregnancy.

Unlock Study Endpoints

Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Intravesical Recombinant Mycobacterium (rMBCG)EXPERIMENTALParticipants will receive an induction course of 1-19.2e8 Colony-forming unit(s) CFU (1 vial) rMBCG via a urinary catheter in the bladder (ie, intravesical administration).

Interventions

NameTypeDescription
Intravesical Recombinant Mycobacterium (rMBCG)BIOLOGICAL19.2e8 Colony-forming unit(s) CFU (1 vial) rMBCG via a urinary catheter in the bladder (ie, intravesical administration)
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 85 Years
SexALL
Healthy VolunteersNo
Study Sites9

Inclusion Criteria: Participants must meet ALL of the following criteria for inclusion in the study: 1. Male or female participants 18 years of age or older. 2. Histologic confirmation of BCG naïve non-muscle invasive urothelial carcinoma of the bladder (mixed histology tumors allowed if urothelia...

Countries:United States
Unlock Eligibility Criteria

Frequently asked questions about Intravesical Recombinant Mycobacterium

What is Intravesical Recombinant Mycobacterium used for?

Intravesical Recombinant Mycobacterium (rMBCG) is an investigational therapy being studied for non-muscle invasive bladder cancer (NMIBC). It is administered intravesically, meaning directly into the bladder, and is currently in Phase 1 clinical development for this indication.

Who makes Intravesical Recombinant Mycobacterium?

Intravesical Recombinant Mycobacterium (rMBCG) is being developed by ImmunityBio, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol IBRX. The company is conducting a Phase 1 clinical trial of this investigational therapy for non-muscle invasive bladder cancer.

What phase is Intravesical Recombinant Mycobacterium in?

Intravesical Recombinant Mycobacterium (rMBCG) is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials for safety and efficacy in patients with non-muscle invasive bladder cancer.

What clinical trials is Intravesical Recombinant Mycobacterium in?

Intravesical Recombinant Mycobacterium (rMBCG) is being studied in a Phase 1 clinical trial with the identifier NCT06800963, titled ResQ133A-NMIBC. This recruiting trial is enrolling approximately 40 participants with non-muscle invasive bladder cancer in the United States, with a minimum age of 18 years.

Is Intravesical Recombinant Mycobacterium the same as rMBCG?

Yes, Intravesical Recombinant Mycobacterium is also known as rMBCG. The drug is referred to by both names in clinical research, and the ongoing Phase 1 trial NCT06800963 uses the rMBCG abbreviation to describe this investigational therapy for non-muscle invasive bladder cancer.