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ENO Lime

Phase 3

Indigestion Acid | Small molecule | Gastrointestinal |Haleon plc|Last Updated: Sep 17, 2025

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

ENO Lime · 1 trial · 3 indications

Phase 3 1
NCT07140341A Clinical Study to Assess the Effectiveness of ENO Lime in Participants With Ajeerna Vyadhi (Acidity, Acid Indigestion, Indigestion, and Associated Nausea)Indigestion Acid
COMPLETED40 Analytics
PHASE3COMPLETED
A Clinical Study to Assess the Effectiveness of ENO Lime in Participants With Ajeerna Vyadhi (Acidity, Acid Indigestion, Indigestion, and Associated Nausea)
Indigestion AcidUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from Baseline in Ajeerna Vyadhi (Acidity, Acid Indigestion, Indigestion, And Associated Nausea) Symptoms Using VAS Scoring After 15 Minutes of Taking ENO Lime
Baseline (0-minutes pre-dose) and 15-minutes post-dose on Day 1

The severity of symptoms of Ajeerna vyadhi will be recorded using VAS scoring. Participants will record a score with a mark at one point along the length of a 100-millimeter (mm) line, where the lowest score 0-mm indicates 'no discomfort' and highest score 100-mm indicates 'worst possible discomfort'. Higher the score, more severe will be the symptoms. Change from baseline will be calculated by subtracting baseline value from the value at 15-minutes.

Secondary Endpoints

Change from Baseline in Ajeerna Vyadhi (Acidity, Acid Indigestion, Indigestion, And Associated Nausea) Symptoms Using VAS Scoring After 2-Minutes, 1-Hour, and 2-Hours of Taking ENO Lime
Baseline (0 minutes pre-dose) and 2-minutes, 1-hour, 2-hours post-dose on Day 1
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ENO LimeEXPERIMENTALParticipants will be instructed to take 1 sachet of ENO Lime powder with approximately 150 milliliters (ml) of normal water as a single dose. Participants will be advised to repeat the dose after 2-hours, if necessary (Maximum 2 sachet per 24-hours). Participants will be followed up for 24-hours.

Interventions

NameTypeDescription
ENO LimeDRUGA fruit salt (sachet of 5-gram powder) with lime flavor containing Svarjiksara (Shudh) 2220 milligram (mg) and Nimbu Rasa (Citrus limon, Fruit Juice Powder) 150 mg
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Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Male and female participants with age 18-60 years (both inclusive). * Participants newly experiencing symptom/s of Ajeerna vyadhi for not more than 10 days. * Participants with at least one symptom of Ajeerna vyadhi (according to Charak Samhita and Madhav Nidan) that is acidit...

Countries:India
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Frequently asked questions about ENO Lime

What is ENO Lime used for?

ENO Lime is used for indigestion and acid indigestion, including associated nausea. It is being studied in a clinical trial for Ajeerna Vyadhi, which covers acidity, acid indigestion, indigestion, and associated nausea. The drug is in Phase 3 clinical development.

Who makes ENO Lime?

ENO Lime is developed by Haleon plc, a company listed on the stock exchange under the ticker HLN. The drug is currently in Phase 3 clinical development for the treatment of indigestion and acid indigestion.

What phase is ENO Lime in?

ENO Lime is in Phase 3 clinical development. It is an investigational drug being studied for indigestion and acid indigestion, including associated nausea. The drug has completed one Phase 3 clinical trial and is not yet approved by regulatory authorities.

What clinical trials is ENO Lime in?

ENO Lime has one completed Phase 3 clinical trial, identified as NCT07140341. This study assessed the effectiveness of ENO Lime in participants with Ajeerna Vyadhi, which includes acidity, acid indigestion, indigestion, and associated nausea. The trial was conducted in India with 40 participants.

Is ENO Lime a small molecule drug?

Yes, ENO Lime is a small molecule drug. It is being developed by Haleon plc for the treatment of indigestion and acid indigestion. The drug is currently in Phase 3 clinical development and is classified under the gastrointestinal therapeutic area.