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HMPL-A580

Phase 2

Solid Tumors, Adult | Small molecule | Oncology |HUTCHMED (China) Limited|Last Updated: Feb 8, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment186
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07396584A Phase I/Ⅱa Study of HMPL-A580 in Participants With Advanced or Metastatic Solid TumorPHASE1/PHASE2 NOT YET_RECRUITING 186Feb 1, 2026Jan 1, 2029Feb 8, 2026 -
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Study Design & Arms
Interventions
NameTypeDescription
HMPL-A580DRUGPart A(Phase I) Dose Escalation Enrolled participants will receive HMPL-A580 treatment in a dose escalation setting initially at 6 predefined dose levels.
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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT07396584studyFirstPostDate: changed