Recent Updates
Recently added Catalysts

orlistat

Phase 1

Overweight | Small molecule | Other |GSK plc|Last Updated: Jan 28, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01550926A Study to Assess the Pharmacologic Equivalence of Two Orlistat Dosage FormsPHASE1 COMPLETED 48Feb 1, 2009Mar 1, 2009Jan 28, 20131 United Kingdom
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Fecal fat excretion
9 days
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
Arm 1ACTIVE_COMPARATOR60 mg orlistat
Arm 2ACTIVE_COMPARATOR120 mg orlistat (2 X 60 mg capsules)
Arm 3EXPERIMENTALorlistat experimental formulation
Interventions
NameTypeDescription
120 mg orlistatDRUG2 X60 mg capsule
60 mg orlistatDRUG60 mg orlistat
orlistat experimental doseDRUGexperimental
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * age: 18-60 years * Body Mass Index: 25-33 Exclusion Criteria: * gastrointestinal disease * organ transplant * HIV, hepatitis B or C * food allergies * alcohol or other substance abuse * smoking

Countries:United Kingdom
Unlock Eligibility Criteria