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ferrous ascorbate

Phase 3

Haematopoiesis | Small molecule | Hematology |GSK plc|Last Updated: Apr 13, 2018

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment271

FDA Designations

No designations recorded

Clinical trial landscape

ferrous ascorbate · 1 trial · 1 indication

Phase 3 1
NCT01160198A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.Haematopoiesis
COMPLETED271 Analytics
PHASE3COMPLETED
A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.
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Study Endpoints

Primary Endpoints

Change From Baseline in Hemoglobin (Hb) After 8 Weeks of Treatment in Each Ferrous Bisglycinate Chelate Group (1 Tablet Daily and 2 Tablets Daily)
Baseline and Week 8

At fortnightly visits, blood was collected for Hb. Baseline (Visit 0) was not more than 5 days from Week 1 or randomization. Change from Baseline was calculated by subtracting Baseline values from post-Baseline values.

Secondary Endpoints

Mean Change in Hb From Baseline to 8 Weeks
Baseline to Week 8
Percentage of Participants Who Achieved a Target Hb More Than or Equal to 12 gm/dL After 8 Weeks of Treatment
Up to Week 8
Mean Change in Hb During 8 Weeks Therapy
Up to Week 8
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Study Design & Arms

AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeOTHER

Treatment Arms

ArmTypeDescription
ferrous bisglycinate chelate 1 ODEXPERIMENTALferrous bisglycinate chelate 1 tablet daily
ferrous ascorbateACTIVE_COMPARATORferrous ascorbate, 1 tablet daily
ferrous bisglycinate chelate 2 ODEXPERIMENTALferrous bisglycinate chelate 2 tablets daily

Interventions

NameTypeDescription
ferrous ascorbateDRUG100 mg elemental iron
ferrous bisglycinate chelate 1 ODDIETARY_SUPPLEMENT60 mg elemental iron
ferrous bisglycinate chelate 2 ODDIETARY_SUPPLEMENT120 mg elemental iron
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Eligibility Criteria

Age Range18 Years to 55 Years
SexFEMALE
Healthy VolunteersNo
Study Sites7

Inclusion Criteria Subjects eligible for enrolment to the study must meet all of the following criteria: 1. Signed and dated written informed consent is obtained prior to participation. 2. Female outpatients between 18 to 55 years of age and using effective method of contraception if sexually acti...

Countries:India
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Frequently asked questions about ferrous ascorbate

What is ferrous ascorbate used for?

Ferrous ascorbate is an investigational small molecule being studied for haematopoiesis, specifically in the context of iron deficiency anaemia. It is being developed by GSK plc (GSK) and is currently in Phase 3 clinical development. The drug is intended to support the production of blood cells.

Who makes ferrous ascorbate?

Ferrous ascorbate is being developed by GSK plc, which trades under the ticker GSK. The company is conducting clinical trials to evaluate the drug's efficacy and tolerability in patients with iron deficiency anaemia. GSK is responsible for the drug's development and regulatory pathway.

What phase is ferrous ascorbate in?

Ferrous ascorbate is in Phase 3 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The Phase 3 trial, NCT01160198, has been completed, and the drug is being evaluated for its efficacy and tolerability in treating iron deficiency anaemia.

What clinical trials is ferrous ascorbate in?

Ferrous ascorbate has one completed Phase 3 clinical trial, NCT01160198, titled 'A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.' The trial enrolled 271 female participants aged 18 years and older in India and was active-controlled but not double-blinded.

Is ferrous ascorbate the same as ferrous bisglycinate chelate?

Ferrous ascorbate is not the same as ferrous bisglycinate chelate. In the clinical trial NCT01160198, ferrous bisglycinate chelate is the investigational drug being compared against ferrous ascorbate, which serves as the active control. They are distinct iron formulations evaluated for their relative efficacy and tolerability in treating iron deficiency anaemia.