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ferrous ascorbate

Phase 3

Haematopoiesis | Small molecule | Other |GSK plc|Last Updated: Apr 13, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment271
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01160198A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.PHASE3 COMPLETED 271Oct 13, 2010Feb 18, 2011Apr 13, 20187 India
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Study Endpoints
Primary Endpoints
Change From Baseline in Hemoglobin (Hb) After 8 Weeks of Treatment in Each Ferrous Bisglycinate Chelate Group (1 Tablet Daily and 2 Tablets Daily)
Baseline and Week 8

At fortnightly visits, blood was collected for Hb. Baseline (Visit 0) was not more than 5 days from Week 1 or randomization. Change from Baseline was calculated by subtracting Baseline values from post-Baseline values.

Secondary Endpoints
Mean Change in Hb From Baseline to 8 Weeks
Baseline to Week 8
Percentage of Participants Who Achieved a Target Hb More Than or Equal to 12 gm/dL After 8 Weeks of Treatment
Up to Week 8
Mean Change in Hb During 8 Weeks Therapy
Up to Week 8
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeOTHER
Treatment Arms
ArmTypeDescription
ferrous bisglycinate chelate 1 ODEXPERIMENTALferrous bisglycinate chelate 1 tablet daily
ferrous ascorbateACTIVE_COMPARATORferrous ascorbate, 1 tablet daily
ferrous bisglycinate chelate 2 ODEXPERIMENTALferrous bisglycinate chelate 2 tablets daily
Interventions
NameTypeDescription
ferrous ascorbateDRUG100 mg elemental iron
ferrous bisglycinate chelate 1 ODDIETARY_SUPPLEMENT60 mg elemental iron
ferrous bisglycinate chelate 2 ODDIETARY_SUPPLEMENT120 mg elemental iron
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Eligibility Criteria
Age Range18 Years — 55 Years
SexFEMALE
Healthy VolunteersNo
Study Sites7

Inclusion Criteria Subjects eligible for enrolment to the study must meet all of the following criteria: 1. Signed and dated written informed consent is obtained prior to participation. 2. Female outpatients between 18 to 55 years of age and using effective method of contraception if sexually acti...

Countries:India
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