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Zilbrix-Hib

Phase 3

Whole Cell Pertussis | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: Aug 18, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment300
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00473668Non-inferiority of GSK Biologicals' DTPw-HBV/Hib Compared to Two Formulations of GSK Biologicals' DTPw-HBV/HibPHASE3 COMPLETED 300Jun 1, 2007Jan 30, 2008Aug 18, 20173 India
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Study Endpoints
Primary Endpoints
Number of Seroprotected Subjects Against Polyribosyl-ribitol-phosphate (PRP) Antigens
At Month 3

A seroprotected subject was defined as a subject with anti-PRP concentrations greater than or equal to (≥) 0.15 microgram per milliliter (µg/mL).

Secondary Endpoints
Number of Seroprotected Subjects Against Hepatitis B Surface Antigen (HBs)
At Month 3
Number of Seroprotected Subjects Against Diphtheria (D) and Tetanus (T) Antigen
At Month 3
Number of Seroprotected Subjects Against Diphteria (D) With Antibody Concentrations Above the Cut-off
At Month 3
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
TRITANRIX-HEPB/HIBERIX KFT. GROUPEXPERIMENTALSubjects, male or female, aged 6 to 8 weeks received 3 doses of Tritanrix™-HepB/Hiberix™ Kft. vaccine, administered intramuscularly in the anterolateral thigh at 6, 10 and 14 weeks of age.
TRITANRIX-HEPB/HIBERIX LD GROUPACTIVE_COMPARATORSubjects, male or female, aged 6 to 8 weeks received 3 doses of Tritanrix™-HepB/Hiberix™ low-dose (LD) formulation vaccine, administered intramuscularly in the anterolateral thigh at 6, 10 and 14 weeks of age.
TRITANRIX-HEPB/HIBERIX HD GROUPACTIVE_COMPARATORSubjects, male or female, aged 6 to 8 weeks received 3 doses of Tritanrix™-HepB/Hiberix™ high-dose (HD) formulation vaccine, administered intramuscularly in the anterolateral thigh at 6, 10 and 14 weeks of age.
Interventions
NameTypeDescription
Zilbrix-HibBIOLOGICALIntramuscular injection, 1 dose
Tritanrix™-HepB/ Hiberix™BIOLOGICALIntramuscular injection, 1 dose
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Eligibility Criteria
Age Range6 Weeks — 8 Weeks
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion Criteria: * Subjects who the investigator believes that their parents/guardians can and will comply with the requirements of the protocol should be enrolled in the study. * A male or female between, and including, 6 and 8 weeks of age at the time of the first vaccination. * Written inform...

Countries:India
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