Recent Updates
Recently added Catalysts

Varilrix HSA-free

Phase 3

Chicken-pox Illness (Varicella Virus Disease) | Monoclonal antibody | Other |GSK plc|Last Updated: Nov 25, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment1,236
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02570126A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age.PHASE3 COMPLETED 1,236Nov 13, 2015Oct 25, 2016Nov 25, 201923 Estonia, Germany +3
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Number of Subjects Reporting Fever
15-days (Days 0-14) post Dose 1 of varicella vaccination

Fever was defined as axillary temperature above (\>) 39.0 °C (\> 102.2°F)

Secondary Endpoints
Number of Subjects Reporting Fever
15 days post each dose of varicella vaccination
Evaluation of Immune Response to Varicella Vaccine With Respect to Anti Varicella Zoster Virus (Anti-VZV) Antibody Concentrations (Immuno-sub Cohort)
At Day 42 and Day 84 post vaccination
Number of Subjects With a Seroresponse to VZV (Immuno Sub Cohort)
At Day 42 and Day 84 post vaccination
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
VAR_HSA_F GroupEXPERIMENTAL2 doses of Varilrix HSA-free vaccine, one at Visit 1 (Day 0) and the other at Visit 2 (Day 42), will be given to the subjects in this group. The vaccine will be administered subcutaneously in the triceps region of the left arm
VAR GroupACTIVE_COMPARATOR2 doses of Varilrix™ vaccine, one at Visit 1 (Day 0) and the other at Visit 2 (Day 42), will be given to the subjects in this group. The vaccine will be administered subcutaneously in the triceps region of the left arm
Interventions
NameTypeDescription
Varilrix HSA-freeBIOLOGICAL2 doses will be administered, one at Day 0 and the other at Day 42
Varilrix™BIOLOGICAL2 doses will be administered, one at Day 0 and the other at Day 42
Unlock Study Design Details
Eligibility Criteria
Age Range12 Months — 23 Months
SexALL
Healthy VolunteersYes
Study Sites23

Inclusion Criteria: * Subjects' parent(s)/ LAR(s) who, in the opinion of the investigator, can and will comply with the requirements of the protocol. * A male or female between, and including, 12 and 23 months of age (i.e. 12 months to a day before 24 months) at the time of the first study vaccinat...

Countries:EstoniaGermanyMexicoThailandUnited Kingdom
Unlock Eligibility Criteria