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Tedivax-Adult/ Td-Rix

Phase 3

Diphteria, Tetanus and Pertussis | Monoclonal antibody | Other |GSK plc|Last Updated: Dec 17, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment116
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01262924Study of Reduced-antigen-content Acellular Pertussis Vaccine and Diphtheria-Tetanus-Acellular Pertussis VaccinePHASE3 COMPLETED 116Oct 1, 1997Dec 1, 1998Dec 17, 2010 -
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Study Endpoints
Primary Endpoints
Immunogenicity with respect to components of the study vaccines (in subjects receiving the dTpa vaccine and Tedivax-Adult™/ Td-Rix™)
One month after the booster dose (Month 1)
Secondary Endpoints
Immunogenicity with respect to components of the study vaccines (in subjects receiving the dTpa, pa vaccines and Tedivax-Adult™/ Td-Rix™)
One month after the booster dose (Month 1)
Occurrence of solicited local adverse experiences
During the 15-day (Day 0-14) follow-up period after vaccination
Occurrence of solicited general adverse experiences
During the 15-day (Day 0-14) follow-up period after vaccination
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group AEXPERIMENTALdTPa vaccine
Group BEXPERIMENTALPa vaccine
Group CACTIVE_COMPARATORTedivax-Adult™/ Td-Rix™
Interventions
NameTypeDescription
GSK Biologicals' reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccineBIOLOGICALIntramuscular, single dose
GSK Biologicals' reduced-antigen-content acellular pertussis vaccineBIOLOGICALIntramuscular, single dose
Tedivax-Adult™/ Td-Rix™BIOLOGICALIntramuscular, single dose or 2 doses (in the annex phase)
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes

Inclusion Criteria: * A male or female aged ≥18 years at the time of vaccination * Free of obvious health problems as established by medical history and clinical examination before entering into the study * Written informed consent obtained from the subject * If the subject is female, she must be o...

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