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Subjects received 3 doses of GSK Biologicals' HPV vaccine

Phase 3

Infections, Papillomavirus | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: Jan 3, 2020

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment152

FDA Designations

No designations recorded

Clinical trial landscape

Subjects received 3 doses of GSK Biologicals' HPV vaccine · 1 trial · 2 indications

Phase 3 1
NCT00637195Immunogenicity and Safety of a Commercially Available Vaccine Co-administered With GSK HPV Vaccine (580299)Infections, Papillomavirus
COMPLETED152 Analytics
PHASE3COMPLETED
Immunogenicity and Safety of a Commercially Available Vaccine Co-administered With GSK HPV Vaccine (580299)
Infections, PapillomavirusUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Subjects Seroprotected Against Hepatitis B Following 3 Doses of Engerix
Month 3

A subject seroprotected against hepatitis B is a subject with anti-hepatitis B surface antigen (HBs) antibody titers greater than or equal to 10 milli-international units per milliliter (mIU/mL).

Anti-hepatitis B Surface Antigen (HBs) Antibody Titers Following 3 Doses of Engerix
Month 3

Titers are given as Geometric Mean Titers (GMTs) expressed as milli-international units per milliliter (mIU/mL).

Secondary Endpoints

Number of Subjects Seroconverted for Anti-human Papilloma Virus 16 and 18 (Anti-HPV-16 and Anti-HPV-18) Antibodies
Months 2 and 7
Anti-HPV-16/18 Antibody Titers
Months 2 and 7
Number of Subjects Seroconverted for Anti-hepatitis B (HBs) Antibodies
Months 2, 3 and 13
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Cervarix™ & Engerix™ GroupEXPERIMENTALSubjects received 3 doses of GSK Biologicals' HPV vaccine (580299) (Cervarix™) (Months 0, 1 \& 6) and 4 doses of Hepatitis B (Engerix™) vaccine (Months 0, 1, 2 \& 12).
Engerix™ GroupACTIVE_COMPARATORSubjects received 4 doses of Hepatitis B (HBV) vaccine (Months 0, 1, 2 \& 12).

Interventions

NameTypeDescription
Subjects received 3 doses of GSK Biologicals' HPV vaccine (580299) (Cervarix™)BIOLOGICALIntramuscular administration, 3 doses.
Engerix™BIOLOGICALIntramuscular administration, 4 doses.
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Eligibility Criteria

Age Range20 Years to 25 Years
SexFEMALE
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Subjects who the investigator believes that they can and will comply with the requirements of the protocol should be enrolled in the study. * A female between, and including, 20 and 25 years of age at the time of the first vaccination. * Written informed consent obtained from ...

Countries:Belgium
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